Author

J. Scott Hale

University of UtahORCID 0000-0003-4318-8472Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Research Focus:cell signaling & trafficking· 2 Research Focus:cell type annotation· 2 Approach:experimental assay· 2 Organism:mouse· 2 Research Focus:chromatin & epigenetic regulation· 1 Assay:DNA methylation· 1 Assay:flow cytometry· 1 Approach:genetic perturbation / CRISPR· 1

Frequent Co-Authors

Andrew BaessleriD· 2 shared Linda M. SircyiD· 2 shared Adolfo García‐SastreiD· 1 shared Andrew G. Ramstead· 1 shared Andrew W. RichensiD· 1 shared Brittany Winter· 1 shared Bryant PerkinsiD· 1 shared Bryce Fuchs· 1 shared

Activity by Year

2024-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 30 mutual co-author links

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2 shared papersImmunology

Andrew BaesslerORCID

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2 papers

Recent·Most cited

ImmunologyCell ReportsPeer-reviewedMar 1, 2026

Dnmt3a-mediated de novo DNA methylation enforces lineage commitment and preserves functionality of memory Th1 and Tfh cells

Bryant Perkins, Camille L. Novis, Andrew Baessler…·J. Scott Hale

This paper shows that Dnmt3a-mediated DNA methylation is essential for maintaining lineage commitment and function of memory Th1 and Tfh cells, and that early inhibition of this process can enhance Tfh cell differentiation.

6 citationstop 1%

mouseDNA methylation

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ImmunologyPLoS PathogensPeer-reviewedSep 16, 2024

Generation of antigen-specific memory CD4 T cells by heterologous immunization enhances the magnitude of the germinal center response upon influenza infection

Linda M. Sircy, Andrew G. Ramstead, Lisa C. Gibbs…·J. Scott Hale

This study shows that heterologous immunization primes antigen-specific memory CD4 T cells, enhancing early germinal center response but not antibody generation in influenza infection.

10 citations

mouseflow cytometry

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