Antimicrobial Resistance in Staphylococcus

This study identifies novel factors regulating YSIRK protein cross-wall trafficking and cell envelope homeostasis in S. aureus through a transposon mutant screen and phenotypic analysis.

This study shows osteoclasts support S. aureus intracellular growth by providing nutrients and a blunted antimicrobial response.

This study shows that orthogonal cell division in Staphylococcus aureus is essential for forming abscess communities by ensuring uniform adhesin distribution and fibrin capsule assembly.

This paper identifies RsaE, a non-coding RNA, as a regulator of psm transcript stability and biofilm properties in MRSA, showing its role in toxin expression, biofilm maturation, and dissemination.

This study identifies nasal commensal bacterial species and combinations that inhibit MRSA, including antibiotic-resistant strains, through in vitro experiments.

This study identifies EssH as a cell wall hydrolase required for T7SSb-mediated protein secretion in S. aureus, revealing its role in facilitating secretion across the cell wall.

This study shows how hyperglycemia and hyperfibrinogenemia alter S. aureus abscess structure, antimicrobial susceptibility, and virulence in vitro using clinical isolates.

This study integrates multi-omic data from Staphylococcus aureus exposed to human serum to identify genetic factors critical for survival, revealing interconnected metabolic, iron transport, and stress response mechanisms.

This study shows that MRSA can exhibit antibiotic sensitivity due to reduced mecA expression and altered PBP2a levels in certain environments, suggesting new therapeutic targets.

The paper introduces a new GWAS method to identify gene-gene associations linked to antimicrobial resistance in Staphylococcus aureus, revealing genetic coalitions beyond known resistance genes.

This study shows how bovine S. aureus adapts to the dairy niche through metabolic remodelling and convergent evolution of protease expression for enhanced growth.

The paper shows mobile genetic elements drive a fusion-deletion cycle in plasmids, shaping their evolution and antimicrobial resistance in Staphylococcus aureus.

This study shows that truncating the Rel protein in S. aureus enhances tolerance to antimicrobial fatty acids by altering cell envelope structure through the SigB-SarA pathway.

This paper identifies a SCCmec-located gene cluster (cst2) that enables MRSA to tolerate polysulfides, giving it a competitive advantage in polysulfide-rich environments.

The paper compares the virulence of different Staphylococcus aureus lineages in bacteremia and infection models, finding significant differences in pathogenicity and identifying key virulence factors.

This study shows that collagen binding adhesin (Cna) in Staphylococcus aureus reduces skin infection severity by binding to C1q and limiting inflammation.

This paper identifies a metabolic adaptation in Staphylococcus aureus that enhances serum resistance without affecting growth, revealing a novel survival strategy in bloodstream infections.

The paper characterizes mobile genetic elements in S. aureus isolates from Uganda, identifying diverse MGEs associated with virulence and antibiotic resistance.

This study shows that the T7SS effector EsxC in S. aureus affects daptomycin sensitivity by modulating cell membrane integrity.

This study compares genetic structure and antimicrobial resistance of VREfm strains from blood and gut samples, finding they are similar and highlighting the importance of preventing gut colonization.

The paper identifies Lactococcus lactis strains that inhibit livestock-associated Staphylococcus aureus in pig nasal microbiomes through sequencing-guided isolation and in vitro testing.

This study identifies TslM as a novel reverse domain arrangement substrate of the Staphylococcus aureus type VII secretion system, revealing its lipase activity and secretion mechanism.

The paper identifies two chromosomal regions, SauTI1 and SauTI2, that restrict horizontal gene transfer in Staphylococcus aureus, highlighting their role in antimicrobial resistance evolution.

This study investigates the internalization of staphylococci into osteoblasts across the genus, finding that half of the species can invade these cells via a conserved FnBP-fibronectin-5β1 integrin pathway.

The paper shows that Hla polymorphisms in MRSA strains affect ADAM10-dependent neutrophil IL-1β secretion and corneal disease severity.

This study demonstrates that a cloud-based bioinformatics platform can rapidly analyze genomic data to detect hospital outbreaks with results comparable to manual analysis, without requiring bioinformatic expertise.

This study identifies MP1-producing S. chromogenes strains with antimicrobial activity and low virulence, suggesting their role as protective commensals in dairy ruminants.

This paper investigates the spatiotemporal regulation of Sae and Agr systems in Staphylococcus aureus during kidney abscess formation, finding Sae activity is heterogeneous and required for abscess progression.

This study uses whole-genome sequencing to analyze S. aureus isolates from Saudi Arabia, revealing higher genetic diversity and antimicrobial resistance in pilgrimage cities compared to non-pilgrimage cities.