Advanced biosensing and bioanalysis techniques

This paper develops an EpCAM-targeted L-DNA nanostructure for targeted doxorubicin delivery in TNBC, showing improved stability and reduced cytotoxicity in normal cells.

This study observes sub-microsecond dynamics of single DNA molecules using graphene-based fluorescence measurements and links findings to structural and environmental factors.

The paper demonstrates a DNA detection method using Mimiviral polymerase X (mvPolX) that is sequence-specific and sensitive, capable of detecting as few as 10 copies of target DNA in 15 minutes.

This paper designs a DNA-based nanoscale Jitterbug transformer that reconfigures its structure in response to chemical and optical signals, maintaining a Poissons ratio of -1.

This paper introduces SONAR, a platform for detecting nucleic acids and triggering gene expression in human cells, demonstrating its ability to sense DNA and RNA and express various protein payloads.

FINDER enables attomolar biomarker detection by converting kinetic fingerprinting into area-scalable sensitivity without amplification.

This paper uses Bayesian optimisation and graph-based rheology to model DNA materials by linking sequence design to material properties.

The paper demonstrates DNA condensate-based organelles that enable spatially regulated gene expression and protein targeting in synthetic cells, showing higher protein yield compared to standard PURE expression.

This paper develops an electrochemical aptasensor for ultrasensitive detection of IL-6 in clinical biofluids, showing high sensitivity and biocompatibility for septic cardiomyopathy diagnostics.

This paper introduces PRO-MOSAIX, a high-accuracy, ultrasensitive multiplex immunoassay that enables 15-plex detection in human plasma with low femtomolar sensitivity.

This study identifies UV-shadowing as a source of errors in DNA strand displacement reactions and proposes a UV-free purification protocol to improve circuit performance.

This study evaluates aptamer and antibody-based sensors for detecting TNF-α in serum using SWCNT optical sensors, finding that modifications improve sensitivity and selectivity.

This paper introduces a platform called INTACT that non-invasively monitors specific mRNA levels in vivo by using synthetic serum markers and RNA-based sensors.

This paper develops a charge-amplified FET biosensor for detecting small-molecule biomarkers with picomolar sensitivity in complex biological samples.

This paper presents a 3D-printed mini-gel electrophoresis system for DNA nanoswitch biosensing, achieving rapid, low-cost, and portable detection of target molecules.

This paper introduces a method to enhance DNA nanoswitch biosensor sensitivity by recycling targets through enzymatic ligation and cyclic annealing, enabling signal amplification without target amplification.

This paper introduces a method to encapsulate gold nanoparticles within DNA origami tubes to improve barcode stability and functionality for multiplexed biomolecular detection.

The paper designs DNA aptamers for Lyme disease detection by combining in silico selection using a Restricted Boltzmann Machine with experimental validation of selected sequences.

This study evaluates how physicochemical factors affect the stability of DNA tetrahedral nanostructures in vitro.

This paper introduces a method to create homogeneous antibody-DNA conjugates using unmodified oligonucleotides and photo-crosslinkable protein G-HUH endonuclease fusion proteins, achieving 1:1 stoichiometry.

This paper optimizes a DNA-based fluorogenic aptamer (D-FAP) using a screening-and-simulation pipeline on a repurposed sequencing platform, achieving improved fluorescence properties.

This paper develops DNA origami caps to selectively functionalize microtubule tips and lattice defects, enabling controlled cargo capture and dynamic visualization.

This study evaluates the effectiveness of aptamer-Cas12a biosensors for small molecule detection, finding limited success and highlighting the need for aptamer validation.

This study identifies DNA aptamers that bind ASFV and show antiviral activity, with Ni2+ enhancing their affinity by 100-fold through a non-canonical DNA motif.

This paper evolves DNA operators to enhance protein-DNA interactions for better transcriptional control in cell-free systems.

This study designs DNA tweezers that selectively bind S100A4 and midkine, biomarkers of glioblastoma invasiveness, using computational methods and molecular docking.

The paper quantitatively analyzes individual ligation reactions in DNA origami nanostructures using qPCR, revealing edge preference and solvent-dependent behavior.

This paper introduces CAptVE, a method for fluorescent aptamer-based labeling that enables molecular analysis in ultrastructurally reconstructable electron micrographs.

This paper identifies DNA aptamers targeting ICAM-1 to inhibit HRV infection by blocking viral entry, showing concentration-dependent antiviral effects in vitro.