Acute Ischemic Stroke Management

The paper investigates the role and mechanisms of leptomeningeal collaterals in human distal MCA territory ischemia using experimental and computational methods.

This study assesses ischemic stroke in nonhuman primates using neuroimaging, behavioral analysis, and serum proteomics to identify biomarkers and understand stroke pathophysiology.

This study shows that inhibiting LOX-1 and MMP-9 with drugs improves outcomes after delayed rt-PA treatment in stroke by reducing hemorrhage and edema.

This paper shows that differences in diffusion imaging protocols affect ADC maps, leading to variations in infarct core volume, location, and clinical score associations in acute stroke.

This study tests argon's neuroprotective effects in a non-human primate stroke model, finding reduced ischemic core volume in treated animals.

This study develops an optimized surgical method to reduce infarct volume variability in C57BL/6 mice by preventing PCA area infarcts and improving reproducibility in the fMCAo model.

This study evaluates the relevance of sham control groups in preclinical cerebral ischemia studies by comparing protein profiles between sham and ischemic groups.

The paper investigates the interaction between APOL1 risk variants and smoking in African Americans, finding that carriers of these variants have increased stroke risk among smokers.

This study shows that post-stroke T3 treatment reduces infarct volumes and stabilizes the blood-brain barrier in mice, with optimal timing and dosage identified.

This study shows that post-recanalization rapamycin treatment improves cerebral blood flow and functional outcomes in rats after ischemic stroke.

This paper predicts stroke outcomes in mice using MRI and behavioral data, finding that lesion volume and topology are key predictors of subacute and residual deficits.

The paper introduces a semi-automated toolkit to estimate stroke infarct volumes in rodents using MRI and histological sections, showing high correlation between the two methods.

This study evaluates minocycline's neuroprotective effects in an aged female rat MCAO model, finding improved neurologic scores and reduced infarct size with treatment.

This study shows that microvascular flow disturbances increase in the ischemic penumbra after middle cerebral artery occlusion in rats, suggesting they are a key factor in tissue outcome.

This paper uses reinforcement learning to recommend drug combinations targeting genes/proteins involved in stroke, showing improved efficacy and reduced p-values in network meta-analysis.

This study investigates the role of IGF-1 signaling in neurons and astrocytes in ischemic stroke, finding that while both contribute to protection, neither is essential for minimizing tissue damage or behavioral outcomes.

This study compares gene expression profiles of stroke-affected tissue across species and time points to identify heterogeneity in stroke-related pathways and gene expression changes.

This study shows that leptomeningeal collaterals regulate reperfusion in ischemic stroke, with poor collaterals leading to hemorrhage and poor outcomes.

This study shows that spreading depolarization during ischemia predicts reperfusion failure and poor outcomes, and inhibiting it improves reperfusion.

This study compares the effects of different anesthetic regimens on MCAO outcomes in male rats, finding that subcutaneous ketamine-xylazine has the lowest mortality rate.

The paper introduces a feature-based method using FDG PET images and SVM to assess MCAO quality in rats, achieving high accuracy in classification.

The paper describes a two-photon photothrombosis protocol to induce depth-targeted single vessel thrombosis in rodent brains with high success rate.

This paper presents a high-resolution micro-CT imaging approach for detailed infarct characterization and automatic segmentation in mouse stroke models.

The paper identifies key genes and pathways associated with stroke types and subtypes using computational methods and finds a prognostic gene signature for stroke risk prediction.

This paper models how cerebral microthrombi affect tissue oxygenation and cell death using computational simulations and a hypoxia-based cell death model.

This study identifies a genetic locus that reduces infarct size after ischemic stroke in mice, independent of collateral vessel anatomy, by uncovering the neuroprotective role of Msr1.

The paper develops an in-silico model to simulate micro-emboli effects on brain microcirculation after thrombectomy, finding capillary beds are more susceptible to occlusion than arterioles.

This study identifies sex-specific lesion patterns in acute ischemic stroke that correlate with stroke severity, highlighting differences in lesion distribution between men and women.

This study shows that peripheral electrical stimulation can increase cerebral collateral blood flow in mice after stroke, but only if applied within the first hour.