Nikolaus Plesnila

This study identifies cerebral microthrombi as focal sites of Cav-1-dependent BBB dysfunction after TBI, linking microvascular thrombosis to neuronal damage through transcytosis.

This paper develops MRI-compatible rigid head holders for mice to enable artifact-free multimodal imaging combining intravital microscopy and MRI.

This study investigates how TREM2 expression levels affect microglial function, metabolism, and response to TREM2 agonists in a mouse model of Alzheimer's disease.

This paper develops a 3D cortical brain tissue model with mature microglia that recapitulates Alzheimer's disease hallmarks and enables study of microglia phenotypes.

GluTrooper is a mouse line for whole-brain glutamate imaging with long-lasting sensor expression and multimodal imaging capabilities.

LipiGo is a DNA-lipid nanoparticle hybrid that enables efficient delivery of functional mRNA to non-hepatic tissues, particularly the spleen, through passive redistribution and active targeting.

The paper introduces anionic cyanine-based plasma membrane probes for live cell and in vivo imaging, showing improved staining and visualization of neuronal structures in mice.

This study identifies innate immune memory after brain injury as a driver of chronic cardiac dysfunction, showing that post-stroke epigenetic changes in myeloid cells lead to inflammation and fibrosis in the heart.

The paper introduces an improved method for collecting and analyzing murine cerebrospinal fluid, enabling quantitative proteomics and revealing proteome changes in Alzheimer's disease models.

This paper develops a real-time FRET-based system to monitor nanocarrier behavior and drug release at post-stroke microthrombi in vivo.

This study develops an optimized surgical method to reduce infarct volume variability in C57BL/6 mice by preventing PCA area infarcts and improving reproducibility in the fMCAo model.

The paper shows pericytes constrict during ischemia, remain constricted post-reperfusion, and contribute to no-reflow, with some surviving and upregulating transcripts, suggesting they are therapeutic targets.

The paper introduces ATUM-Tomo, a hybrid method combining SEM and electron tomography for multi-scale ultrastructural analysis of cellular structures.

This study demonstrates DNA origami can be directed in vivo to target immune cells and cancer metastases, showing potential for precision drug delivery.

This study shows that FHM1 mutations in CaV2.1 channels worsen outcomes after TBI by increasing CSDs, seizures, and brain edema in mice.

This study shows that glycolic acid protects neurons from ischemic damage by reducing calcium-mediated excitotoxicity during reperfusion in stroke models.

The paper shows that BID interacts with VDAC1 to mediate mitochondrial permeabilization and neuronal cell death in response to stress.