Acute Ischemic Stroke Management

Dual MMP-9/12 Inhibition with AZD1236 Confers Neurovascular Protection and Reduces Post-Stroke Pain in Experimental Stroke Models.

This study evaluates AZD1236, a dual MMP-9/-12 inhibitor, showing reduced infarct/hematoma volumes, improved neurological outcomes, and pain mitigation in stroke models.

Proteomic and Transcriptomic Differences in Ischemic Stroke Patients with Atrial Fibrillation Versus Carotid Atherosclerosis

The paper identifies proteomic and transcriptomic differences between ischemic stroke patients with atrial fibrillation and carotid atherosclerosis using integrated multi-omics analyses.

Knockdown of endothelial Serpine1 improves stroke recovery by attenuating peri-infarct blood flow and blood brain barrier disruption

This study shows that reducing Serpine1 in endothelial cells after stroke improves recovery by reducing blood flow and preventing blood-brain barrier damage.

Peptidylglycine α-amidating monooxygenase restores brain microvascular blood flow and improves recovery following ischemic stroke

This study shows that administering PAM improves capillary blood flow and reduces infarct volume in rats after ischemic stroke, leading to better neurological recovery.

Dual-action nanoconjugate for overcoming r-tPA -resistant clots

This study develops a dual-action nanoconjugate combining r-tPA and DNase to target r-tPA-resistant clots, showing improved reperfusion and reduced lesion volume in an ischemic stroke model.

Senolytic treatment guided by carotid stenosis confers protection against acute ischemic stroke in aged rodents

Senolytic treatment with dasatinib plus quercetin after carotid artery occlusion reduces infarct size and improves outcomes in aged rodents with ischemic stroke.

Early Prediction of Ischaemic Stroke Outcomes: A Novel Computational Approach

This paper introduces a computational pipeline to predict brain swelling after stroke using a mathematical model and deep neural network, achieving an AUC of 0.7 in predicting 3-month outcomes.

Quantitative Imaging of the Heterogeneity of Brain Potassium Depletion in Experimental Focal Ischemia

The paper quantitatively images brain potassium depletion in ischemic stroke, showing heterogeneous K+ dynamics between peripheral and central ischemic core regions not linked to neuronal degradation.

Hemodynamic and electrophysiological progression of the Rose Bengal photothrombotic stroke model in mice: vasoactive properties of Rose Bengal, tissue heating, wavelength optimization, and sex differences in lesion volume

This study characterizes the hemodynamic and electrophysiological effects of the Rose Bengal photothrombotic stroke model in mice, identifying confounding factors and sex differences in stroke outcomes.

Excellent agreement between automated deep learning-based and manual DWI infarct volume measurement in hyperacute stroke

This study evaluates the agreement between automated deep learning-based and manual DWI infarct volume measurements in hyperacute stroke, finding excellent agreement and comparable predictive performance.

Multimodal Characterization and Evolution of Malonate-induced Stroke Model: advanced MRI, Histology-Molecular Profiling

This paper characterizes the temporal evolution of ischemic injury in a rat model using MRI and molecular analysis, revealing changes in lesion volume, vascular function, inflammation, and angiogenesis.

Standardizing the mouse MCAO Stroke Model: Distinguishing Internal Carotid vs Pterygopalatine Artery Occlusion

This study standardizes the mouse MCAO stroke model by distinguishing ICA and PPA occlusion, showing 15-minute ICA occlusion balances infarction and survival best.

Neuroanatomical Basis of Coma in Acute Ischemic Stroke

This study identifies brainstem and thalamus lesions as necessary and sufficient for coma in acute ischemic stroke, highlighting lesion location over volume in coma pathogenesis.

CT Radiomic Signatures of Neutrophil Extracellular Traps in Ischemic Stroke Thrombi

This paper identifies radiomic features from CT scans that predict neutrophil extracellular trap (NET) enrichment in ischemic stroke clots, which correlates with mechanical thrombectomy success.

Inflammatory Markers are Associated with Ischemic Stroke among Indigenous Africans: Evidence from the SIREN Study

The paper investigates the association between inflammatory biomarkers, stroke severity, and outcomes in indigenous Africans using data from the SIREN cohort.

Tryptophan metabolites as biomarkers to predict the severity and prognosis of acute ischemic stroke patients

This study identifies tryptophan metabolites as biomarkers for predicting 3-month functional outcomes in acute ischemic stroke patients.

Head down tilt 15° increases cerebral perfusion before recanalization in acute ischemic stroke: a pre-clinical MRI study.

This study shows that head down tilt 15° increases cerebral perfusion and reduces infarct growth in a rat model of acute ischemic stroke before recanalization.

Intra-arterial Deoxyribonuclease therapy improves stroke outcomes in aged mice

This study shows that intra-arterial DNase therapy improves stroke outcomes in aged mice by enhancing reperfusion and reducing NETs.

Preclinical systematic review of CCR5 antagonists as cerebroprotective and stroke recovery enhancing agents

This study reviews preclinical evidence on CCR5 antagonists' effects on stroke outcomes and recovery, finding reduced infarct volume and improved behavioral outcomes, but highlighting significant bias and knowledge gaps.

Neutrophil extracellular traps block endogenous and intravenous thrombolysis-induced fibrinolysis in large vessel occlusion acute ischemic stroke

This study shows that neutrophil extracellular traps (NETs) inhibit fibrinolysis during intravenous thrombolysis in acute ischemic stroke by sequestering tPA and plasminogen, and that DNase 1 can enhance thrombolysis by removing NETs.

Multi-center Translational Trial of Remote Ischemic Conditioning in Acute Ischemic Stroke (TRICS BASIC)

TRICS BASIC tested remote ischemic conditioning in experimental stroke, finding improved functional outcomes and reduced infarct volume in rodents.

Harnessing micrometer-scale tPA beads for high plasmin flux and accelerated fibrinolysis

This paper develops micrometer-scale tPA beads that enhance plasmin generation and fibrinolysis, achieving rapid thrombus removal in a mouse stroke model with lower doses than standard tPA.

MicroRNAs and mRNA Regulatory Network of Parenchymal Hematoma after Endovascular Mechanical Reperfusion for Acute Ischemic Stroke in Rat

The paper identifies microRNA and mRNA regulatory networks associated with parenchymal hematoma after mechanical reperfusion in a rat stroke model.

Inhibition of nitric oxide synthase transforms carotid occlusion-mediated benign oligemia into de novo large cerebral infarction

The paper investigates how NOS inhibition transforms benign oligemia into large cerebral infarction in mice and links SDMA levels to ischemic stroke risk in humans.

Type 2 diabetes remodels collateral circulation and promotes leukocyte adhesion following ischemic stroke

This study uses two-photon microscopy to show that T2DM impairs collateral circulation and increases leukocyte adhesion after ischemic stroke, leading to poor recovery and worse outcomes.

Thrombolysis exacerbates cerebrovascular injury after ischemic stroke via a VEGF-B dependent effect on adipose lipolysis

This study shows that thrombolysis worsens cerebrovascular injury after ischemic stroke by increasing adipose lipolysis, which can be mitigated by VEGF-B antagonism.

A minimally invasive thrombotic stroke model to study circadian rhythm in awake mice

This paper develops a minimally invasive thrombotic stroke model in mice that allows for reperfusion therapy and in vivo imaging, showing it produces reproducible infarcts and is ameliorated by tPA.

Development of endothelial-targeted CD39 as a therapy for ischaemic stroke

This paper develops an endothelial-targeted CD39 therapy for ischaemic stroke, showing reduced infarct size and improved BBB integrity when administered 3 hours post-ischaemia.

Stress hyperglycemia exacerbates inflammatory brain injury after stroke

This study shows that post-stroke hyperglycemia worsens brain injury by increasing oxidative stress and impairing motor recovery in mice.

Roles and mechanisms of leptomeningeal collaterals in human distal MCA territory ischemia

The paper investigates the role and mechanisms of leptomeningeal collaterals in human distal MCA territory ischemia using experimental and computational methods.