Glaucoma and retinal disorders

This study examines the distribution of glial cell markers in the rat optic nerve, finding heterogeneous expression patterns that suggest physiological stress in the distal-most region.

This paper introduces a luminescence assay to detect myocilin secretion defects in trabecular meshwork cells and confirms secretion issues for several mutant variants.

The paper compares the morphology of astrocytes in the lamina cribrosa and glial lamina across species to understand their role in glaucoma.

This study investigates the structural and cellular behavior of the A427T myocilin mutant, showing structural similarity to wild-type but inefficient degradation, which contributes to glaucoma pathogenesis.

This study examines how optic nerve injury affects the electrophysiological properties of a resilient retinal ganglion cell type, finding reduced firing and intrinsic excitability due to voltage-gated channel dysfunction and Ca2+-dependent mechanisms.

This study identifies OPTN's role in axonal mitochondria transport and shows its loss contributes to neurodegeneration in models of ALS and NTG.

This paper uses robotic visible-light OCT to visualize segmental Schlemms canal anatomy and its response to pilocarpine in mice, showing segmental changes in volume.

This study performs single-cell RNA sequencing on primary human trabecular meshwork cells in vitro to compare gene expression with in situ tissue, providing a public resource for studying cellular identity and translatability.

The paper shows that impaired mitophagy in retinal ganglion cells contributes to glaucomatous neurodegeneration and that pharmacological or genetic correction can rescue this damage.

This study evaluates how elevated IOP affects lamina cribrosa oxygenation using experimental and computational models in monkeys, finding significant hypoxia at IOP levels above 30 mmHg.

This study develops and evaluates patient-centred polygenic risk score reports for glaucoma screening using qualitative interviews to assess preferences and understanding.

The paper identifies resident tissue macrophages as critical for maintaining intraocular pressure homeostasis by regulating extracellular matrix turnover in the trabecular meshwork.

This study develops a rat model of traumatic optic neuropathy (TON) through rapid eye rotation, showing visual deficits and biomarker changes, suggesting its utility for TON research and early diagnosis.

This study measures anterior and posterior chamber volumes in mice, finding the anterior chamber constitutes 47% of total aqueous humor volume, significantly different from humans, and suggests previous inflow rate estimates may be overestimated.

This paper introduces a multiparametric grading system to stratify post-mortem glaucoma tissue by disease severity using structural and molecular markers.

This paper introduces a fluorescent Slc17a6-tdTomato mouse model for visualizing retinal ganglion cells and assessing neurodegeneration in vitro and in vivo.

This study shows that oral Nicotinamide Riboside (NR) treatment protects retinal ganglion cells (RGCs) and optic nerve axons in DBA/2J mice, likely through increased retinal NAD+ levels, and also prevents iris depigmentation and delayed IOP elevation.

A magnetic cell therapy reduced intraocular pressure in a glaucoma mouse model, with hAMSCs showing greater efficacy than iPSC-TM cells.

This study identifies LXB4's role in regulating microglia in the optic nerve during ocular hypertension, showing it reduces disease-associated microglia and promotes homeostasis.

The paper proposes an axon-centric method to quantify IOP-induced mechanical insults on retinal ganglion cell axons, revealing distinct longitudinal and transverse strain patterns.

This study examines microglia morphology and gene expression in the visual thalamus of glaucoma mice, finding morphological changes and immune gene upregulation linked to intraocular pressure and synapse loss.

The paper performs transcriptomic analyses of Schlemm's canal endothelial cells to reveal their lymphatic identity, three major cell states, and interactions with trabecular meshwork cells.

This study shows that autophagy disruption reduces mTORC1 activation, leading to retinal ganglion cell degeneration in glaucoma, and identifies potential therapeutic targets.

This study identifies SARM1 as a key driver of retinal ganglion cell degeneration in ADOA and shows its suppression prevents degeneration phenotypes.

This study develops a novel Cre-inducible mouse model of myocilin glaucoma that replicates key human disease features, showing impaired axonal transport precedes retinal ganglion cell loss.

This study uses finite element analysis to identify iris and anterior chamber factors influencing angle closure during pupil dilation, finding that smaller anterior chamber depth and width, and larger iris thickness and convexity increase angle narrowing.

This study compares proteomic changes in retinal ganglion cells under glutamate excitotoxicity and optic nerve crush, identifying unique and shared alterations in protein profiles.

This study uses finite element modeling to show that eye morphology and tissue stiffness significantly affect optic nerve head deformations during gaze shifts.

This study shows that microglia depletion in aged mice increases optic nerve damage in glaucoma models, suggesting microglia protect against ocular hypertension-induced retinal ganglion cell loss.

The paper uses Nanostring technology to profile IOP-responsive genes in rat trabecular meshwork and optic nerve head tissues under controlled intraocular pressure conditions.