Glaucoma and retinal disorders

IOP-independent treatment for neurodegeneration in glaucoma using optimized ROS-scavenging microparticles for sustained release of erythropoietin

This paper develops ROS-scavenging microparticles for sustained EPO release to treat glaucoma neurodegeneration, showing neuron preservation in animal models.

Plasma Proteogenomics Identifies RGMB as a Candidate for Primary Open-Angle Glaucoma Detected Only in East Asians

The paper identifies RGMB as a potential risk factor for East Asian POAG through proteogenomic analysis, showing ancestry-specific associations and lack of colocalization with IOP traits.

Endothelin 2-Mediated Neuroinflammation Drives Hypertension-Associated Retinal Dysfunction

This study shows that endothelin-2 drives hypertension-related retinal dysfunction through neuroinflammation, independent of intraocular pressure, and identifies EDNRA as a therapeutic target.

Transcriptomic profiling of normal and glaucomatous trabecular meshwork cells in a tissue-like soft ECM environment

The paper identifies 588 differentially expressed genes in glaucomatous versus normal trabecular meshwork cells cultured in a soft ECM environment, revealing three disease-related programs.

Therapeutic AIBP expression contributes to synaptic preservation and vision restoration against glaucomatous neuroinflammation

This paper shows that AAV2-hAIBP preserves retinal ganglion cells and visual function in glaucoma without lowering intraocular pressure by targeting neuroinflammation through the AIBP-TLR4 axis.

Angiopoietin-like protein 7 (ANGPTL7)-mediated effects on resident immune cells contribute to neurodegeneration in glaucomatous optic nerve head

This study shows ANGPTL7 affects immune cells in the optic nerve head, contributing to neurodegeneration in glaucoma, despite no effect on intraocular pressure.

Variant-to-gene mapping in ocular cell types identifies candidate effector genes for primary open-angle glaucoma

This study maps POAG risk variants to candidate effector genes in ocular cell types, identifying ARHGEF12 as a potential target.

Total RNA Sequencing Reveals Early Coding, Noncoding, and Isoform-Level Transcriptomic Changes Following Traumatic and Glaucomatous Optic Nerve Injury

The paper uses RNA sequencing to identify early transcriptomic changes in mouse retinas after optic nerve injury, revealing differential expression of protein-coding genes, lncRNAs, and alternative splicing events.

Experimental Assessment of Iris Water Content and Sex Differences in Mature Rabbits

The paper experimentally measures iris water content and sex differences in rabbits, finding higher water content in males and minimal PBS effect on females.

VEGFA-Positive Macrophages Regulate Aqueous Humor Outflow in Aged Mice and Humans

This study identifies VEGFA-producing macrophages around Schlemm's canal as a compensatory mechanism maintaining aqueous humor outflow during aging and vascular stress, suggesting TIE2 activation as a therapeutic target.

Genetic discovery using deep learning-derived optic nerve integrity phenotypes

The paper uses AI-derived retinal thickness phenotypes from 2D images to identify novel genetic loci for neurodegenerative diseases.

RGC-specific reversal of lipid peroxidation drives neuroprotection and vision restoration in optic nerve ischemia by targeting GPX4

This study identifies lipid peroxidation as a driver of neurodegeneration in NAION and shows that GPX4 overexpression protects RGCs and restores vision.

PEG-Arginase 1: A Novel Therapy for Optic Nerve Injury

This paper demonstrates that PEG-A1 treatment reduces retinal injury and preserves vision after optic nerve trauma by modulating the ornithine/polyamine pathway.

Molecular profiling implicates immune-driven adaptive homeostasis in maintaining intraocular pressure with age

The paper uses single-cell RNA sequencing to identify age-related immune remodeling in ocular outflow tissues that may help maintain intraocular pressure.

Modeling Retinal Ganglion Cell Degeneration from Longitudinal Intraocular Pressure Trajectories

The paper models retinal ganglion cell degeneration using longitudinal intraocular pressure data to identify cumulative exposure as a key predictor of disease progression.

Multimodal Fusion of Circular Functional Data on High-resolution Neuroretinal Phenotypes

This paper develops a multimodal fusion method for high-resolution neuroretinal rim phenotypes, identifying structural heterogeneity and clinically relevant degeneration regions.

Multiomic analysis of non-glaucomatous human trabecular meshwork cells.

This study provides a comprehensive multiomic analysis of non-glaucomatous human trabecular meshwork cells using data from multiple laboratories.

BXD51: A Robust and Translational Mouse Model for Studying the Pathophysiology of Glaucoma

This study characterizes the BXD51 mouse strain as a reproducible model of chronic progressive glaucoma, showing distinct clinical and structural features compared to other strains.

Transcriptomic Profiling of High vs. Low Flow Regions of Mouse and Human Trabecular Meshwork

The paper compares transcriptomic differences between high and low flow regions in mouse and human trabecular meshwork to understand intraocular pressure regulation.

Involvement of Mitophagy in Endothelin-1 Mediated Neurodegeneration in Rodent Models of Glaucoma

This study investigates how endothelin-1 affects mitophagy in retinal ganglion cells and optic nerve in glaucoma models, finding differential responses in these regions.

Short-term psychosocial outcomes following disclosure of glaucoma polygenic risk score (INSiGHT Study)

This study examines the short-term psychosocial effects of receiving glaucoma polygenic risk scores, finding limited knowledge but small reductions in anxiety and stress, with higher-risk individuals showing more negative emotions.

Segmental outflow and trabecular meshwork stiffness in an ocular hypertensive mouse model

This study examines how dexamethasone-induced ocular hypertension affects segmental outflow and trabecular meshwork stiffness in mice, finding no significant stiffness differences but increased fibronectin in low-flow regions.

An Integrated muti-omics cell atlas of the human trabecular meshwork and ciliary body

The paper creates a multi-omics atlas of human trabecular meshwork and ciliary body cells, identifying cell types and regulatory programs linked to glaucoma.

Metabolic Intervention with Dimethyl Malonate Impairs Phagocytic Clearance but Fails to Protect Neurons

This study tests if inhibiting succinate oxidation with dimethyl malonate protects neurons after optic nerve injury but finds it impairs phagocytosis and fails to reduce inflammation.

Pharmacogenomics of steroid-induced ocular hypertension: relationship to high-tension glaucomas and new pathophysiologic insight

The paper identifies 44 SNPs associated with steroid-induced ocular hypertension using a pharmacogenomic approach.

A paradoxical relationship between mitochondrial calcium regulation and retinal ganglion cell degeneration after axon damage

This study shows that higher mitochondrial calcium levels predict retinal ganglion cell survival after optic nerve injury, but reducing mitochondrial calcium increases survival, revealing a paradoxical relationship.

PROX1 loss in adult mouse Schlemm's canal causes permanent ocular hypertension

This study shows that loss of PROX1 in adult mouse Schlemm's canal leads to permanent ocular hypertension by converting the canal to a vein-like phenotype.

Pitx2-associated early-onset glaucoma alters corneal innervation and sensory function in a sex-specific manner

This study shows that Pitx2-associated glaucoma causes sex-specific changes in corneal nerve structure and sensory function, with females showing more inflammatory and stress-related changes than males.

Microtubule stability modulates Schlemm's canal cell mechanobiology and outflow facility in glaucoma

This study shows that microtubule stability affects Schlemm's canal cell mechanics and outflow facility in glaucoma by altering contractility, stiffness, and pore formation.

IOP-induced blood-retinal barrier compromise contributes to RGC death in glaucoma

This study shows that elevated intraocular pressure compromises the blood-retinal barrier, leading to vascular leakage and retinal ganglion cell death in glaucoma models.