Glaucoma and retinal disorders

The paper identifies a missense variant in OLFML3 as a candidate for severe goniodysgenesis and glaucoma in Border Collies.

This study investigates the roles of MKK4 and MKK7 in retinal development and RGC death after axonal injury, finding that their deficiency increases RGC survival but disrupts retinal structure when both are absent.

This study examines the differential loss of retinal ganglion cell subtypes after optic nerve crush in rats, finding that alpha- and direction selective-RGCs are more susceptible to loss compared to ip-RGCs.

This study identifies differentially expressed miRNAs and genes in human trabecular meshwork cells under cyclic mechanical stretch, highlighting miRNA-mRNA regulatory interactions in glaucoma-related pathways.

This study shows that targeting complement C3 with gene therapy reduces neurodegeneration in glaucoma by protecting retinal ganglion cells.

This study shows that PRSS56 is essential for proper positioning of ocular angle structures during development, leading to angle closure and elevated intraocular pressure in mice.

This study shows that combining inhibition of apoptosis and necrosis can transiently protect retinal ganglion cells and promote partial axon regeneration after optic nerve damage.

The paper identifies a genomic locus on chromosome 8 associated with intraocular pressure (IOP) regulation in BXD RI mouse strains, with Cdh11 as the most likely candidate gene.

This study identifies a genomic locus on Chromosome 18 associated with retinal ganglion cell loss in a mouse glaucoma model.

The paper identifies a genomic locus modulating corneal thickness in mice and links it to POU6F2, a potential risk factor for glaucoma.