Glaucoma and retinal disorders

This study shows that loss of tenascin-C reduces reactive gliosis and increases anti-inflammatory cytokines in an autoimmune glaucoma mouse model.

This paper develops a glaucoma-on-a-chip model to assess RGC viability under high pressure and tests neuroprotective agents.

This study shows that hPSC-derived RGCs with the OPTN(E50K) mutation display neurodegenerative phenotypes, providing insights into glaucoma mechanisms.

The paper shows that microglia activation occurs in the contralateral eye of unilateral glaucoma models, suggesting the contralateral eye may not be a valid control.

This study identifies early metabolic and inflammatory changes in microglia from a glaucoma mouse model and shows radiation therapy reverses these changes.

This study shows that overexpressing MCT2 in glaucoma models preserves retinal ganglion cells and improves energy homeostasis by enhancing ATP production and mitochondrial function.

This study compares proteomic changes in a rat glaucoma model with human glaucoma, identifying shared and distinct molecular features related to oxidative stress, mitochondrial dysfunction, and immune pathways.

The paper identifies rare protein-altering variants in ANGPTL7 that lower intraocular pressure and reduce glaucoma risk by analyzing genotyping data from UK Biobank and FinnGen.

The paper shows oral pyruvate protects against glaucomatous neurodegeneration in mice by improving bioenergetics and inhibiting mTOR.

This study shows that loss of AKAP1 leads to Drp1 dephosphorylation, mitochondrial fragmentation, and RGC dysfunction in glaucoma, suggesting AKAP1 as a therapeutic target.

The paper identifies POU6F2 as a marker for a novel group of ON-OFF directionally selective retinal ganglion cells that are sensitive to glaucomatous injury.

The paper identifies a novel POAG-associated SNP in African Americans using a genome-wide association study.

The paper develops an instrumented tweezers system to measure optic nerve crush forces and establishes a correlation between axon loss and force-impulse in mice.

The paper tests simultaneous IOP and PERG measurements during LDP and finds IOP changes affect PERG amplitudes in lower eyes.

The paper identifies biallelic CPAMD8 variants as a cause of congenital glaucoma with anterior segment dysgenesis in four individuals from three families.

The paper shows that removing senescent cells early in a mouse model of ocular hypertension protects retinal ganglion cells from loss and preserves visual function.

This paper develops a deep variational autoencoder to estimate glaucoma progression rates and predict future visual field loss, showing improved performance compared to traditional methods.

The paper identifies neuroprotective genes in retinal ganglion cells by analyzing their resilience to injury using single-cell RNA-seq and functional assays.

This study investigates the role of DDIT3 in RGC somal loss and axonal degeneration in DBA/2J mice with chronic ocular hypertension, finding that DDIT3 contributes to somal loss but not axonal degeneration.

This study examines how mechanical fluid flow affects ECM gene and protein expression in HTM cells, finding reduced fibronectin and collagen IV levels.

This study shows that early-stage ocular hypertension causes pre- and post-synaptic functional and structural changes at retinogeniculate synapses before significant RGC loss.

This study uses OCT to measure retrograde degeneration in patients with homonymous hemianopia, finding earlier and more severe thinning in anterior lesions compared to posterior ones.

This study investigates the protective effects of HIOC and TUDCA on retinal ganglion cell (RGC) death following optic nerve crush in mice, finding significant RGC survival in treated groups.

This study shows that blocking the IL-1 pathway with anakinra reduces retinal inflammation and preserves retinal ganglion cell function and structure after blast-induced TBI in mice.

This study links diffusion MRI measures of optic nerve integrity to clinical glaucoma markers in patients using semi-automated tractography.

This paper develops a reversible mouse model of secondary glaucoma using silicone oil and validates it for testing neuroprotective therapies.

This study trains a deep learning model to predict future 24-2 Humphrey Visual Fields up to 5.5 years ahead using historical data from glaucomatous patients.

This study shows that increasing Ucp2 expression in retinal ganglion cells protects against glaucoma-induced cell death, but transcriptional activation alone is insufficient for neuroprotection.

This study shows that deleting UCP2 in mice reduces retinal ganglion cell death in glaucoma by increasing mitophagy and mitochondrial quality control.