Mitochondrial Function and Pathology

This study shows GH promotes TNBC progression through DRP1-mediated mitochondrial fission, linking metabolic reprogramming to cell-cycle progression and tumor microenvironment changes.

The paper investigates the role of mitochondrial calcium dynamics at the axon initial segment (AIS) in action potential generation and finds they are dispensable for this function.

This study identifies mitoEV-mediated mitochondrial transfer from astrocytes to neurons as a compromised pathway in early Alzheimer's disease, revealing its role in supporting neuronal energy metabolism.

This study shows PS1 localizes to mitochondrial inner membrane and regulates cristae structure by modulating protein interactions at cristae junctions, leading to mitochondrial dysfunction in Alzheimer's disease.

The paper investigates how mitochondrial replication components form multiphasic condensates and shows how ssDNA and dsDNA are segregated by architectural proteins.

This study identifies PPR9 as essential for mitochondrial RNA splicing, complex I biogenesis, and early Arabidopsis development.

The study shows MitoTracker transfers from astrocytes to neurons without requiring mitochondrial transfer.

This study identifies PP2A's role in regulating mitochondrial dynamics via MAPK signaling in heart failure, showing hyperphosphorylated ERK2 drives fission and contributes to cardiomyopathy.

This study shows that ECM signals induce mitochondrial elongation and activity through actin polymerization and integrin signaling in mammospheres.

The paper shows OMA1 regulates mitochondrial protein import and OXPHOS biogenesis under stress by degrading DNAJC15, affecting protein translocation and organelle communication.

This study investigates the structural and dynamic effects of the m.14849T>C variant in Cytochrome b, showing localized perturbations in the heme bL microenvironment that may contribute to multisystem mitochondrial disease.

This study identifies Complex I as essential for maintaining mitochondrial membrane potential during infection with virulent bacteria, revealing distinct strategies used by Legionella and Salmonella.

The paper uses experimental and computational methods to analyze mitochondrial energy metabolism in cardiac mitochondria, revealing new insights into substrate transport, TCA cycle kinetics, and oxidative phosphorylation.

The paper investigates transcriptomic and methylomic changes in HEK 293T cells with reduced mtDNA copy number, revealing compensatory mechanisms in mitochondrial replication and metabolic pathways.

The paper infers mtDNA deletion accumulation times from scRNAseq data in mouse muscle cells, finding mean accumulation times of ~3 months.

The paper develops a rule-based model to generate synthetic mitochondrial targeting sequences in yeast and demonstrates their functionality in directing proteins to mitochondria.

This study identifies AltSLC35A4, an AltORF-encoded protein, as a regulator of mitochondrial DNA homeostasis by interacting with actomyosin cytoskeletal components and affecting mtDNA spatial distribution.

This study profiles mitochondrial respiration in IBM muscle tissue, identifying sex-specific impairments in respiration and OXPHOS complexes, along with correlations with disease severity.

This study shows that TAFAZZIN deficiency disrupts mitochondrial maturation in cardiomyocytes, leading to structural and functional impairments associated with Barth syndrome cardiomyopathy.

This study shows that impairing polymerase gamma activity in cardiomyocytes leads to mtDNA instability, activates the integrated stress response, and causes severe cardiomyopathy with hepatopathy in mice.

The paper develops an assay to quantify canine mitochondrial DNA copy number and evaluates its potential as a biomarker for acute brain injury.

This study identifies EFHD1 as a Ca2+-dependent stabilizer of ER-mitochondrial contacts that drives liver injury in MASH by promoting mitochondrial fragmentation and antiviral stress responses.

This study investigates the role of the glycerol phosphate shuttle in energy coupling and thermogenesis in Drosophila flight muscle, showing it enhances heat production while regenerating NAD+.

The paper identifies fedratinib as a drug that increases endoplasmic reticulum-mitochondria contact sites by inhibiting BRD4, revealing a novel epigenetic pathway linking ERMCS to cellular metabolism.

This study shows that vitamin D3 protects brain mitochondria from calcium-induced damage, improves bioenergetics, and enhances redox balance in rats.

This study shows NRF1-primed MSCs enhance mitochondrial transfer to endothelial cells, improving mitochondrial function and reducing oxidative stress.

The paper investigates mitochondrial proteome homeostasis through multiomic analyses of gene perturbations, revealing post-transcriptional regulation and new protein functions.

This study identifies small molecule modulators of TFAM that increase its levels and mtDNA copy number, reducing mtDNA stress and inflammation in disease models.

This study shows that reducing Complex III in macrophages during viral infection dampens inflammation, improving recovery from H1N1 influenza.

This study shows that cognate amino acid treatment improves growth, neuromuscular function, and reduces stress in 19 C. elegans models of mt-ARS deficiency.