Hearing, Cochlea, Tinnitus, Genetics

This study shows that distorted tonotopy, not reduced temporal precision or broader tuning, severely impairs neural representation of natural speech in noise after acoustic trauma.

This study shows that selective attention modulates theta-range auditory nerve activity in humans, with a classifier decoding attended modality from single-trial data.

The paper identifies two distinct types of nodes of Ranvier in the mouse auditory nerve and shows their functional roles and changes across development and aging.

This study uses cryo-electron tomography to visualize the molecular structure and conformation of tip-links in mouse stereocilia, revealing their stoichiometry and clustering.

This study examines if recreational noise exposure alters biomarkers of cochlear synaptopathy, finding no significant changes except for a learning effect in speech audiometry.

This study investigates the relationship between programmed cell death in the cochlea and macrophage recruitment during development, finding that macrophages are not essential for tissue remodeling.

This paper models tinnitus-like hallucinations in an entropy maximization recurrent neural network by simulating sensory deprivation and showing how it drives the network into a tinnitus-like state.

The paper shows small cells in the cochlear nucleus use olivocochlear collaterals to encode sound in noise, with superior intensity and envelope coding.

This study shows that CHD7 protects auditory neurons and hair cells from stress-induced degeneration, with implications for CHARGE syndrome.

This study shows mechanical overstimulation causes acute injury and synapse loss in zebrafish neuromasts, but recovery occurs rapidly.

This paper identifies Klhl18 mutant mice with low-frequency progressive hearing loss due to inner hair cell dysfunction, showing abnormal stereocilia and normal outer hair cell function.

This study determines the optimal parameters for the parallel auditory brainstem response (pABR) to estimate hearing thresholds efficiently in clinical settings.

The paper examines the spatial and temporal expression of PORCN in the developing mouse cochlea, showing its dynamic role in Wnt-mediated medial compartment specification.

This study shows that expressing Atoh1 and Ikzf2 in adult cochlear supporting cells converts them into Prestin+ outer hair cell-like cells, advancing OHC regeneration.

This study examines auditory system recovery after mild blast trauma in rats over two months, finding multiphasic recovery with persistent central deficits.

This study develops a method to induce hair cell ablation in zebrafish and shows that these cells regenerate in vivo.

The paper identifies six variants in four genes associated with hearing loss in four South Indian families, highlighting genetic and phenotypic heterogeneity.

This study investigates how Mpv17 affects mitochondrial function and synapse integrity in zebrafish hair cells under stress, finding impaired mitochondrial activity leads to increased vulnerability and altered synaptic morphology.

The paper develops a mathematical framework to define the conditions for a place code in the auditory system, showing how frequency and intensity can be encoded through spatial and cluster size representations in neural networks.

The paper investigates Ca2+ influx mechanisms in cochlear outer hair cells, finding that synaptic VGCCs and MOC synapses contribute differently to Ca2+ homeostasis, with sorcin playing a regulatory role.

The paper investigates synaptic plasticity in ascending and descending pathways to MOC neurons, finding opposing short-term plasticity and a wide dynamic range of firing.

This study shows that Piezo2 in outer hair cells is essential for ultrasonic hearing in mice, but not for low-frequency hearing.

This study investigates how FOXO3 protects cochlear cells from noise-induced damage in mice, finding that its absence leads to increased cell death and hearing loss, with LPA treatment offering partial protection.

The paper develops a method to rapidly stimulate inner-ear hair cells using photonic force, demonstrating its application to vestibular and cochlear hair cells.

This study identifies MPDZ's role in maintaining apical cytoskeleton patterning in hair cells, showing its necessity for stereocilia alignment and preventing hearing loss in Mpdz mutants.

This study shows that a novel temporally complex acoustic environment improves temporal processing in a mouse model of congenital hearing loss.

The paper investigates how glycinergic axonal inhibition enables precise spatial sensitivity to sudden sound intensity changes by analyzing binaural circuits in the auditory system.

This study links tinnitus development to inner hair cell synaptopathy in Mongolian gerbils following acoustic trauma, independent of hearing loss severity.

This study identifies TMEM43 mutations as a cause of autosomal dominant auditory neuropathy spectrum disorder by showing their interaction with Connexin-mediated channels in cochlear glia-like supporting cells.

The paper investigates residual inhibition (RI) in tinnitus patients using EEG, finding differences in alpha and gamma band activity between responders and non-responders, suggesting trait-like oscillatory signatures in tinnitus subgroups.