Wei Xiong

This study identifies LPHN2 as a force-sensing GPCR critical for auditory function, showing its role in mechanoelectrical transduction and hearing loss when deficient.

This study identifies LPHN2/ADGRL2 as a force-sensitive adhesion GPCR essential for normal equilibrioception by regulating mechanoelectrical transduction in utricular hair cells.

This study identifies CIB2 as a Ca2+ sensor in auditory mechano-electrical transduction and links TMC1 genetic variants to hearing loss through structural and functional analysis.

This paper introduces a wireless mini-microscope (wScope) for real-time brain imaging in freely moving animals, enabling simultaneous recording from up to 8 mice.

This paper identifies the medial sector of the auditory thalamus (ATm) as an interface that transforms alerting environmental cues into internal arousal and emotional state changes in mice.

The paper identifies opposing transcription signals mediated by CaV1-encoded DCT peptides and shows they are regulated by C-terminus mediated inhibition.

This study shows that Piezo2 in outer hair cells is essential for ultrasonic hearing in mice, but not for low-frequency hearing.

This study demonstrates that NHEJ-mediated frame restoration can efficiently correct frameshift mutations in vivo, restoring function in a mouse model of Usher syndrome.

This study identifies TMC1 as providing a background leak conductance in mouse auditory hair cells, essential for action potential firing and tonotopic organization.

This study investigates whether TRPV5, TRPV6, TRPM6, and TRPM7 contribute to hair-cell mechanotransduction and finds they are unlikely to be the pore-forming subunit of the transduction channel.