Eric Gouaux

The paper maps AMPA and NMDA receptors at mouse hippocampal synapses using cryo-ET, revealing their distribution and relationship to glutamate release sites.

The paper investigates the structure and gating mechanism of GluN3A-containing NMDA receptors, showing how glycine activates them and how CGP-78608 modulates their activity.

This study develops a mouse model of anti-AMPAR encephalitis and shows that autoreactive B cells and plasma cells accumulate in the brain, driving disease progression.

This study optimizes single molecule assays to detect and quantify the native hair cell mechanosensory transduction complex at attomole levels.

This study determines the structure of human BASIC with and without Ca2+ using cryo-EM and shows Ca2+-dependent conformational changes in the transmembrane domain and β-linkers, revealing how Ca2+ modulates ion flow through the channel.

The paper develops methods to image glutamatergic synapses in hippocampal tissue using cryo-electron tomography, enabling high-resolution visualization of synaptic structures.

This paper isolates and characterizes the serotonin transporter (SERT) from porcine brain, revealing its monomeric state and structural interactions with psychostimulants like methamphetamine and cocaine.

The paper identifies three structural populations of GABAARs in mice, revealing how neurosteroids modulate receptor structure and function.

This study uses cryo-electron tomography to visualize the molecular structure and conformation of tip-links in mouse stereocilia, revealing their stoichiometry and clustering.

This study investigates the molecular mechanisms of partial agonist action and conformational transitions in the glycine receptor using electrophysiology, MD simulations, and cryo-EM.

This study develops an active immunization model in mice that mimics anti-NMDA receptor encephalitis, revealing neuroinflammation and immune cell involvement in disease pathogenesis.

The paper presents the cryo-EM structure of a triheteromeric GABAA receptor complexed with GABA, revealing mechanisms of receptor assembly and agonist binding.