Circadian rhythm and melatonin

This study shows that diurnal antelope ground squirrels do not shift their activity patterns in response to cyclic aversive stimuli, unlike nocturnal rodents.

This study shows HSP83 regulates Pdf transcription in clock neurons, affecting behavioral plasticity and circadian rhythms in Drosophila under stress.

This study shows melatonin reduces lipid accumulation and leptin resistance in 3T3-L1 cells by activating PI3K/AKT signaling through MT1/MT2 receptors.

The paper uses lineage correlations and a small molecule inhibitor to detect circadian control of the cell cycle in colon cancer cells.

This study shows that dim light at night increases seizure-like events and disrupts sleep in Cntnap2 knockout mice, with sex-specific effects.

This study identifies ZFHX3's role in regulating circadian gene expression in the SCN by mapping its genomic binding sites and analyzing transcriptomic changes in ZFHX3 mutants.

This study identifies non-visual opsin expression in multiple tissues of the green anole lizard, highlighting tissue-specific patterns and evolutionary conservation.

This study shows that mitofusin 2 regulates mitochondrial and synaptic dynamics in SCN VIP neurons, affecting circadian rhythms and sleep in mice.

The paper investigates subunit shuffling dynamics in KaiC's central hub, revealing how ATPase activity regulates this process in the cyanobacterial circadian clock.

This study examines how different levels of melanopic illuminance affect cognitive performance and workload, finding non-linear relationships with both positive and negative effects at moderate and extreme light levels.

This study shows that cryptochrome loss in marine bristleworms increases lifespan and size, with hormonal pathways linked to sexual development and reproduction.

This study identifies a molecular pathway where melatonin promotes sleep by activating BK channels (Slo1) via MT1 receptors in SCN neurons, revealing a core circadian mechanism for sleep regulation.

This study conducts a GWAS of human pineal gland volume, identifying 34 genome-wide significant loci and highlighting genes and pathways related to sleep, metabolism, and neurodegeneration.

HairTime estimates chronotype from a single hair sample, showing it is influenced by age, sex, and work schedules, with lower circadian amplitude reducing prediction accuracy.

The paper identifies and analyzes circadian clock and light-input pathway genes in Hemiptera, revealing lineage-specific gene losses and splicing variants, as well as a horizontal gene transfer event.

The paper introduces D-CAF, a framework for co-expression analysis of multi-omic time-series data, identifying novel circadian-regulated pathways in mouse macrophages.

This study investigates how neuropeptides Dh31 and Dh44 modulate spike time precision and plasticity in Drosophila circadian output neurons, revealing their role in circadian clock neural coding for sleep.

The paper examines the correlation between circadian clock parameters and photoperiodic latitudinal clines in Drosophila littoralis, finding they align with diapause induction thresholds.

This study identifies circadian clock subtypes in breast cancer and shows their impact on drug sensitivity.

This study identifies SCN Neuromedin-S neurons as regulators of arousal, sleep-wake cycles, and body temperature rhythms through circuit analysis and single-nuclei RNA-Seq.

This study identifies phod1 as a gene regulating seasonal energy metabolism via the growth hormone pathway in Japanese medaka fish.

This study examines structural and functional changes in intrinsically photosensitive retinal ganglion cells (ipRGCs) in Alzheimer's disease, finding severe loss and altered function of these cells that may contribute to circadian rhythm disruption.

The paper shows that melanopsin ganglion cells, not rod/cone photoreceptors, drive the pupillary light reflex under high light conditions in mice.

This study investigates the protective effects of BMAL1 overexpression in the suprachiasmatic nucleus on neurovascular deficits in diabetic mice, showing improvements in circadian rhythms, retinal function, and glucose homeostasis.

This study identifies diurnal variation in mitochondrial function as a key determinant of time-of-day-dependent exercise capacity in skeletal muscle.

This study identifies circatidal gene expression rhythms in the deep-sea shrimp Rimicaris leurokolos, revealing a 12-hour oscillation pattern distinct from circadian rhythms and similar to ultradian rhythms in other species.

The paper identifies a conserved PER-DBT interaction critical for circadian timing and temperature compensation through structural and functional analyses in Drosophila and human cells.

This study shows that evening blue light exposure in adolescent mice increases avoidance behaviors and changes medial amygdala circuitry.

This study shows visible light affects behavioral memory and gene expression in C. elegans through a non-visual pathway involving cyp-14A5 and bZIP transcription factors.

The paper develops a method to infer circadian rhythm disruptions in tumors using phase differences between clock genes, finding cancer-type-specific alterations affecting patient survival.