Circadian rhythm and melatonin

This study uses VR head-mounted displays to deliver standardized light stimuli and finds melatonin suppression in 75% of participants.

This study compares circadian transcriptomic rhythms in mouse and human prefrontal cortex subregions, finding conserved signaling with sex-specific phase shifts and species-specific rhythmic transcript identities.

This study examines how sex, mating status, and genetic background affect circadian behavior in Drosophila, finding sex-specific period length differences and mating status-dependent rhythm strength changes.

The paper investigates how the waveform of regulatory functions affects period fluctuations in the circadian output system and finds that sinusoidal regulation minimizes these fluctuations.

This study examines how temperature affects circadian clock function in two Nothofagus tree species, revealing species-specific thermal limits and impacts on growth and survival.

This study shows that the Drosophila circadian clock influences gut microbiome composition and daily bacterial load, with some bacteria having their own circadian rhythms.

This study shows that melatonin, not light, primarily drives circadian regulation of melanin synthesis and melanophore proliferation in Xenopus laevis, with melatonin mimicking dark-phase gene expression.

This study identifies RITMO1 as a key circadian regulator in the diatom Phaeodactylum tricornutum, showing its impact on fluorescence, photosynthesis, and clock-controlled gene expression.

The paper shows that the dorsal vagal complex has circadian rhythms regulated by meal timing, with clock genes and their targets expressed rhythmically in vivo.

This study investigates how temperature affects the fold-switching mechanism of KaiB, a circadian clock protein, showing that proline isomerization is a rate-limiting step.

This study shows that daily glucocorticoids influence glioblastoma growth and circadian synchronization with the host, with effects dependent on timing and clock genes.

This study shows that light affects glucose and lipid metabolism in mice through the sympathetic nervous system, independent of circadian rhythms, and that these effects can be reversed with light exposure.

This study shows that cardiomyocyte Bmal1 is essential for sex-specific gene expression in the adult mouse heart, as its loss reduces sex differences in circadian transcriptomes.

The paper develops MITE to infer functional connectivity in the SCN and finds a conserved, sparse connectome with hubs that drive circadian synchrony.

The paper maps the synaptic connectome of the Drosophila circadian clock, revealing additional neurons, contralateral connectivity, and novel peptidergic signaling.

The paper investigates temperature-sensitive alternative splicing of the clk gene in Drosophila and its role in regulating circadian clock function through phosphorylation site deletion.

This paper introduces ROSLT, a Raspberry-Pi-based cyclometer for tracking mouse voluntary wheel running, showing it provides more accurate and consistent measurements than VDO M2.1 over time.

The paper shows that lack of PER in Drosophila leads to genotoxic stress in neuronal progenitors during development.

This study examines how circadian disruption and alcohol consumption affect gene expression in reward-related brain areas of female rats, finding distinct impacts on clock genes and inflammatory markers.

The paper investigates the role of clock genes period and timeless in regulating synaptogenesis and rhythmic changes in synaptic bouton numbers in Drosophila motor neurons.

The paper develops methods to quantify ambient light for mammals using species-specific photoreceptor-based measurements, showing improved physiological prediction compared to lux.

This study shows that heat-killed Streptococcus pneumoniae increases circadian clock gene expression in zebrafish cells via a reactive oxygen species-dependent pathway.

This study identifies sex-specific roles of NPAS2 in fentanyl reward and addiction mechanisms in mice and humans.

The paper shows that hepatic vagal afferents transmit circadian signals between the liver and brain, influencing food intake and body weight.

CosinorTest is an R Shiny app for circadian and differential analysis of transcriptomic data using Cosinor models, offering tools for rhythmicity detection, differential pattern assessment, and visualization.

This study shows how light at night influences the circalunar and circasemilunar clocks in Clunio marinus through strain-specific integration of light intensity, duration, and timing.

This study shows that genetic variation in the period gene affects daily and seasonal timing in Ostrinia nubilalis, with reduced per mRNA abundance linked to later activity and shorter diapause.

This study shows that age-related blood-borne factors alter circadian gene expression in cultured fibroblasts, affecting oxidative phosphorylation and cholesterol biosynthesis pathways.

This study identifies osteopontin expression in both M2 and M4 intrinsically photosensitive retinal ganglion cells, challenging its exclusive association with M4-ipRGC.

This study investigates how varying light levels affect different regions of the human hypothalamus during cognitive tasks, finding distinct activity patterns linked to task performance.