Circadian rhythm and melatonin

The paper shows that Drosophila clock neurons release neuropeptides from different compartments at different times, with somatic release controlled by IP3 and terminal release by Ca2+.

This study models the circadian regulation of the immune system in shift workers, showing sex-specific effects on immune response to inflammation.

The paper describes a model in flies that uses daily neural circuit rewiring to predict environmental light changes based on time-of-day.

This study shows that stress-susceptible mice have blunted diurnal firing in LHb-DRN projections and slower photoentrainment, while resilient mice maintain normal rhythms and faster entrainment.

The paper shows light and circadian clock impair neural stem cell growth and proliferation in Drosophila by affecting the InR/TOR pathway.

The paper identifies multiple mechanisms by which Drosophila clock neurons transmit time-of-day signals to the pars intercerebralis to regulate circadian behaviors.

This study identifies co-expression networks of core clock genes in different cell types during brain development using single-cell RNA sequencing data.

The paper measures single-cell mRNA dynamics of core-clock genes in mouse fibroblasts and develops a probabilistic model to decompose mRNA variability, showing circadian phase is encoded post-transcriptionally.

This study investigates the role of D1R signaling in food anticipatory activity (FAA) in mice, finding that while D1R promotes FAA, other dopamine receptors also contribute.

The paper shows that circadian regulation in macrophages involves extensive post-transcriptional control of the proteome, influencing metabolic states and immune functions.

The paper investigates circadian rhythms in liver chromatin organization and transcription, finding both clock-controlled and clock-independent chromatin structures regulate physiological functions.

This study shows that human sleep timing synchronizes with the lunar cycle under natural conditions, with sleep onset delayed and duration shortened before the full moon.

The paper characterizes Drosophila circadian neurons using single-cell RNA sequencing, identifying 17 cell categories with time-dependent gene expression patterns.

This paper investigates how TMT-opsins modulate medaka brain function differently in various contexts, revealing non-additive interactions and behavioral impacts.

This study shows the chi-square periodogram (CSP) underestimates biological rhythm periods, especially in short time-courses, and recommends using alternative methods like the Lomb-Scargle periodogram.

The paper identifies mRNAs regulated by Neat1 deletion in rat pituitary cells, revealing both circadian and non-circadian effects and their association with key biological processes.

This study identifies miR-183/96/182 as a circadian modulator through a genome-wide miRNA screen and validates its function in vitro and in vivo.

The paper models how multiple random phosphorylations in clock proteins generate delays and switches necessary for circadian oscillations.

The paper identifies Rorc as a key regulator of circadian transcriptome amplitude variation across mouse tissues by analyzing publicly available circadian transcriptome datasets.

This study identifies Period-2 and Nonsense Mediated Decay as regulators of CKI levels, affecting circadian period in Neurospora crassa.

The paper identifies the hyperpolarization-activated cation current Ih as essential for circadian and sleep behaviors in Drosophila by enabling high-frequency neuronal bursting in lateral ventral neurons.

The paper identifies TIM phosphorylation sites in Drosophila and shows that CK2-dependent phosphorylation of TIM(S1404) regulates nuclear export and circadian rhythms, with implications for human FASPS.

The paper characterizes mWake expression in the adult mouse brain, identifying its presence in neurons and non-neuronal cells across multiple brain regions and providing single-cell RNA sequencing analysis of hypothalamic mWake+ cells.

This study shows that the CBP KIX domain is essential for long-term memory and circadian rhythms by regulating CREB and CLOCK target genes.

This study shows that Pigment-dispersing factor (PDF) signaling is essential for olfactory associative memory in Drosophila, with distinct effects on appetitive and aversive memory based on circadian timing.

This study shows conventional RGCs innervate ipRGC-recipient nuclei beyond the suprachiasmatic nucleus, revealing distinct stratification patterns and innervation differences.

The paper develops unsupervised methods to extract sleep and circadian features from wearable data, identifies 53 novel genetic loci associated with sleep, circadian rhythms, and related traits.

The paper identifies daily oscillating transcripts in the hippocampus of control and epileptic mice, showing distinct circadian patterns and implications for drug timing.

The paper shows that cold exposure causes chromatin compaction and nuclear retention of circadian clock transcripts, which resets the circadian rhythm upon rewarming.

The paper develops a mathematical model to explain how eS6 phosphorylation integrates circadian and diel signals to detect daylength changes.