Circadian rhythm and melatonin

The paper identifies SCN enhancers with 24-hour rhythmic H3K27ac modulation and links them to gene expression cycles through RNA-Seq and eRNA analysis.

The paper presents the cryo-EM structure of the CRY:TIM complex, revealing molecular mechanisms of circadian clock timing and light entrainment.

Kronos is an R-based tool for analyzing circadian rhythms in biological datasets, supporting complex study designs and high-dimensional omics data.

The paper shows that light affects eclosion and locomotor activity in Drosophila through distinct sensory pathways.

This study shows that gradual exposure to a fragmented day-night cycle induces reversible circadian arrhythmia in mice.

This study investigates the role of lin-42 and kin-20 in the circadian clock of C. elegans using a bioluminescence reporter, showing they regulate the period length through neuronal cells.

The paper identifies synaptic protein alterations and circadian rhythm disruptions in brain regions associated with opioid use disorder using proteomics.

This study shows chronic corticosteroid exposure disrupts circadian regulation of hippocampal function and synaptic plasticity in rats, leading to memory loss.

The paper examines time-of-day-dependent transcriptome and metabolome variations in human NAFL and NASH livers, finding disruptions in rhythmic gene expression and metabolites.

The paper develops a mathematical model showing how spatially coordinated phosphorylation of PER protein ensures precise and robust circadian rhythms despite spatiotemporal noise.

The paper investigates how SCN neurons maintain circadian oscillations despite ion channel variability, revealing ion-channel degeneracy and a plasticity manifold that enable stable transitions.

This study shows that terminal uridylation of mRNA is rhythmic in mouse liver and that knocking down TUT4 and TUT7 disrupts circadian rhythms.

This study shows that human CLOCK has extra-circadian functions in the neocortex, enhancing cognitive flexibility and neural connectivity through altered gene expression in excitatory neurons.

The paper shows that antisense RNA qrf transcription is not required for circadian clock function in Neurospora crassa, but its evening rhythm is controlled by the morning repressor CSP-1.

The paper identifies a leptin-responsive hypothalamic circuit that influences circadian feeding rhythms by modulating SCN activity and food entrainment.

This study shows that Bmal1 and Per2 in the nucleus accumbens reduce alcohol consumption in male mice, but not in females, with Bmal1's effect being specific to the nucleus accumbens in females.

This study shows CLOCK and TIMELESS regulate daily rhythmic BRM chromatin-remodeling activity at clock gene promoters in Drosophila.

This study shows coupling enables robust circadian rhythms in redox oscillators despite noise and heterogeneity.

The paper investigates day-night and seasonal gene expression variation across human tissues using GTEx data, finding unique patterns in different tissues and conserved clock gene differences across species.

Circadian phase inference of 914 GTEx donors reveals sex- and age-dependent rhythmic gene expression programs across 46 human tissues.

The paper identifies circadian gene expression patterns in mouse renal proximal tubules and provides a web resource for these data.

This study shows that mouse dentate granule neurons exhibit a 24-hour excitability oscillation regulated by G-protein signaling and Bmal1, affecting memory and spatial discrimination.

This paper uses in vivo calcium imaging and electrophysiology to show AVP neurons in the SCN exhibit unstable single-cell rhythms but coherent network activity with a strong circadian rhythm.

Browser-based cosinor fitting for circadian and ultradian rhythms with no install; 24-hour results matched two existing programs, ultradian results diverged slightly from one of them.

The paper shows that timed activation of VIP neurons in the SCN and late afternoon light exposure can rescue dysregulated estrus cycles in mice.

This study identifies a novel circadian feedback loop between Per1 and Per2 genes in CA1 that mediates mood-related behaviors, with Per1 promoting Per2 expression and Per2 inhibiting Per1, contributing to depression and bipolar disorder pathophysiology.

This study identifies novel regulators of Nutritional Compensation in the circadian clock of Neurospora crassa and shows conservation in mammalian cells.

This study identifies age-dependent and tissue-specific changes in the circadian transcriptome of male mice, showing reduced rhythmic gene expression and increased variability in aged tissues.

The paper identifies three distinct circadian phases in Drosophila pacemaker networks and shows how they drive rhythmic activity in downstream neurons.