Circadian rhythm and melatonin

The paper identifies nighttime-specific gene expression changes in the habenula and suprachiasmatic nucleus of stress-resilient mice compared to stress-naive mice.

This study uses Mendelian randomization to identify genetic links between chronotype and brain volume differences outside the suprachiasmatic nucleus in the UK Biobank.

This study shows AVP neurons determine the circadian period of the SCN network by controlling behavioral rhythms through period lengthening.

This study investigates how aging affects the circadian transcriptome of the pancreas across a full circadian cycle, revealing reorganization and new rhythmic patterns in extrinsic cellular pathways.

This study shows environmental circadian disruption rewrites liver circadian gene expression rhythms, affecting metabolism, and these changes persist after recovery.

This study examines how the amplitude of diurnal rhythms relates to brain structure in individuals with different chronotypes, finding correlations in the visual cortex and middle temporal gyrus.

The paper identifies 8 functional subtypes of rodent ipRGCs and shows they have distinct photosensitivity and response timing, with varying performance under different light conditions.

The paper uses RNA-seq data from Drosophila melanogaster selected for sleep duration to identify gene interactions underlying phenotypic changes using a Gaussian Process model.

This study shows that loss of functional dpCry1 in monarch butterflies disrupts circadian eclosion and flight activity rhythms, but not temperature entrainment, indicating a unique role for dpCRY1 in light entrainment.

This paper identifies chlorhexidine as a circadian clock activator that promotes myogenesis through enhanced CLOCK/Bmal1 transcriptional activity.

The paper shows that the circadian clock regulates rhythmic lipid transport in Drosophila hemolymph, influenced by diet, light, and feeding patterns.

The Circadia Study investigates circadian rhythm disorders through a home-based approach to collect data and improve understanding of their genetics and treatment.

TW68, a Cryptochrome stabilizer, reduces fasting blood glucose in diabetic mice by enhancing CRY stability and decreasing gluconeogenic gene expression.

The paper uses CRISPR-based methods to disrupt circadian genes in specific Drosophila neurons, revealing distinct functions of cryptochrome and PDF in circadian behavior.

This study shows that chronic social stress in mice dampens core body temperature and thermosensitive gene rhythms in the lateral habenula, with faster recovery of temperature rhythms in resilient mice.

This study shows fetal circadian rhythms develop early in pregnancy and synchronize with the maternal rhythm, influenced by maternal glucocorticoids.

This paper performs a meta-analysis of mouse liver transcriptomics data to assess consistency of biological rhythms across studies, finding high concordance for core clock genes but low overlap for other rhythmic genes.

This study uses single-cell time-lapse microscopy to show that RpoD4 pulses at cell division and links the circadian clock and cell cycle in Synechococcus elongatus.

The paper identifies genetic variants associated with the loss of mechanical entrainment in circalunar clocks of marine midges, revealing a complex genetic architecture and candidate genes involved in the trait.

This study investigates circadian re-entrainment in Alzheimer's disease mouse models, finding faster re-entrainment in 3xTg and 5xFAD mice, independent of microglia or tau pathology, suggesting altered light sensing contributes to circadian behavior changes.

The paper identifies a new vascular portal pathway from the SCN to the OVLT, showing circadian-regulated blood flow and AVP transport, suggesting a mechanism for circadian signaling.

This study examines how cocaine and morphine affect diurnal proteome rhythms in the mouse nucleus accumbens, revealing distinct pathway alterations.

The paper investigates how Bmal1 rescue and time-restricted feeding affect liver and muscle proteomes in mice, finding BMAL1 has a greater impact than feeding cycles.

This study tests a home-based protocol for measuring circadian phase via salivary DLMO, showing feasibility and accuracy in 10 participants.

The paper identifies circadian gene expression patterns in Drosophila using single-cell and bulk RNA-seq, revealing three mechanisms for generating daily gene expression rhythms.

This study examines circadian genetic architecture in fibroblasts to assess its contribution to bipolar disorder risk, finding limited gene expression patterns and no significant genetic associations with BD.

This study shows that sleep deprivation, fragmentation, and social jet lag in Drosophila increase temperature preference, suggesting a link between sleep disruption and thermoregulation through specific clock neurons.

The paper defines and analyzes two types of amplitude-period correlations in circadian rhythms and shows their impact on oscillator-environment interactions.

The paper shows that astrocytic GABA transporters regulate extracellular GABA levels in the SCN, which in turn controls circadian time-keeping through neuronal inhibition.

The paper identifies robust ~12h transcriptional rhythms in human peripheral white blood cells under free-living conditions, showing homology to circatidal gene programs in marine species.