Circadian rhythm and melatonin

The paper shows that DMV neuronal activity varies daily and is modulated by diet, with high-fat diets paradoxically increasing daily variation but reducing responsiveness to metabolic neuromodulators.

This paper introduces likelihood-based methods to detect circadian rhythmicity and differential circadian patterns in transcriptomic data, showing improved error control and power in simulations and real data.

This study shows that higher daytime light intensity increases circadian rhythm amplitude in the diurnal rodent Rhabdomys pumilio by affecting SCN electrophysiological activity.

The paper creates a merged SBGN PD map of the circadian clock and cell cycle, validates its dynamics, and identifies NR1D1's role in regulating cell cycle progression.

This study examines how a 3-hour weekend light shift disrupts circadian rhythms in Drosophila, leading to desynchrony in neural networks and behavioral defects.

This study shows that Per1 and Per2 regulate myoblast differentiation and muscle regeneration through Igf2 activation, creating a circadian time window for these processes.

This study profiles the diurnal transcriptome of the benthic diatom Seminavis robusta, revealing rhythmic gene expression patterns and adaptations to its environment.

This study finds that travelers' expectations, not circadian factors like time zones crossed or travel direction, predict jetlag symptom severity.

This study shows that developmental circadian disruption in mice alters placental gene expression and immune cell markers, potentially increasing adult chronic disease risk.

The paper shows that Drosophila clock neurons release neuropeptides from different compartments at different times, with somatic release controlled by IP3 and terminal release by Ca2+.

This study models the circadian regulation of the immune system in shift workers, showing sex-specific effects on immune response to inflammation.

The paper describes a model in flies that uses daily neural circuit rewiring to predict environmental light changes based on time-of-day.

The paper develops a stochastic oscillator model to simulate how light entrains zebrafish circadian clocks and applies it to predict effects of pharmacological treatments on entrainment dynamics.

This study shows that stress-susceptible mice have blunted diurnal firing in LHb-DRN projections and slower photoentrainment, while resilient mice maintain normal rhythms and faster entrainment.

The paper shows light and circadian clock impair neural stem cell growth and proliferation in Drosophila by affecting the InR/TOR pathway.

The paper identifies multiple mechanisms by which Drosophila clock neurons transmit time-of-day signals to the pars intercerebralis to regulate circadian behaviors.

This study identifies co-expression networks of core clock genes in different cell types during brain development using single-cell RNA sequencing data.

The paper measures single-cell mRNA dynamics of core-clock genes in mouse fibroblasts and develops a probabilistic model to decompose mRNA variability, showing circadian phase is encoded post-transcriptionally.

This study shows that AD mouse models have impaired clock gene expression and disrupted diurnal regulation of hippocampal inhibitory transmission and spatial memory.

This study investigates the role of D1R signaling in food anticipatory activity (FAA) in mice, finding that while D1R promotes FAA, other dopamine receptors also contribute.

The paper shows that circadian regulation in macrophages involves extensive post-transcriptional control of the proteome, influencing metabolic states and immune functions.

The paper investigates circadian rhythms in liver chromatin organization and transcription, finding both clock-controlled and clock-independent chromatin structures regulate physiological functions.

The paper examines the suprachiasmatic nucleus (SCN) to identify intermediate structures called phaseomes through phase differences and connectivity gradients, revealing anisotropy in network organization.

This study shows that human sleep timing synchronizes with the lunar cycle under natural conditions, with sleep onset delayed and duration shortened before the full moon.

The paper describes a new portal system connecting the suprachiasmatic nucleus (SCN) and organum vasculosum of the lamina terminalis (OVLT) in the brain, suggesting new routes for secreted signals and redefining brain communication pathways.

This study investigates how varying light intensity and duration affect the human circadian system using full-field flashes and measures circadian phase shifts and melatonin suppression.

The paper characterizes Drosophila circadian neurons using single-cell RNA sequencing, identifying 17 cell categories with time-dependent gene expression patterns.

This paper investigates how TMT-opsins modulate medaka brain function differently in various contexts, revealing non-additive interactions and behavioral impacts.

This study shows the chi-square periodogram (CSP) underestimates biological rhythm periods, especially in short time-courses, and recommends using alternative methods like the Lomb-Scargle periodogram.