Circadian rhythm and melatonin

The paper identifies mRNAs regulated by Neat1 deletion in rat pituitary cells, revealing both circadian and non-circadian effects and their association with key biological processes.

This study uses machine learning to analyze sleep and eating schedules from 500 participants, proposing a framework to classify chronotypes and assess circadian misalignment for health guidance.

The paper investigates whether diurnal rhythm affects cognitive performance in healthy adults and finds no significant effect of testing time on cognitive test results.

The paper shows that human pain sensitivity follows a circadian rhythm, primarily driven by the endogenous circadian system rather than sleep.

This study identifies miR-183/96/182 as a circadian modulator through a genome-wide miRNA screen and validates its function in vitro and in vivo.

The paper models how multiple random phosphorylations in clock proteins generate delays and switches necessary for circadian oscillations.

The paper identifies Rorc as a key regulator of circadian transcriptome amplitude variation across mouse tissues by analyzing publicly available circadian transcriptome datasets.

This paper expresses human tau proteins in specific Drosophila clock circuits and shows how it disrupts sleep and circadian rhythms in different ways.

This study identifies Period-2 and Nonsense Mediated Decay as regulators of CKI levels, affecting circadian period in Neurospora crassa.

The paper identifies age-specific circadian gene expression patterns in Botryllus schlosseri and links them to aging phenotypes and pathways.

The paper identifies the hyperpolarization-activated cation current Ih as essential for circadian and sleep behaviors in Drosophila by enabling high-frequency neuronal bursting in lateral ventral neurons.

The paper identifies TIM phosphorylation sites in Drosophila and shows that CK2-dependent phosphorylation of TIM(S1404) regulates nuclear export and circadian rhythms, with implications for human FASPS.

The paper characterizes mWake expression in the adult mouse brain, identifying its presence in neurons and non-neuronal cells across multiple brain regions and providing single-cell RNA sequencing analysis of hypothalamic mWake+ cells.

This study shows that the CBP KIX domain is essential for long-term memory and circadian rhythms by regulating CREB and CLOCK target genes.

This study shows that Pigment-dispersing factor (PDF) signaling is essential for olfactory associative memory in Drosophila, with distinct effects on appetitive and aversive memory based on circadian timing.

This study shows conventional RGCs innervate ipRGC-recipient nuclei beyond the suprachiasmatic nucleus, revealing distinct stratification patterns and innervation differences.

The paper confirms that Pitx3ak mice do not entrain behavioral and metabolic rhythms to light-dark cycles but can entrain to feeding schedules, suggesting a minimal dopamine neuron population is sufficient for food entrainment.

The paper develops unsupervised methods to extract sleep and circadian features from wearable data, identifies 53 novel genetic loci associated with sleep, circadian rhythms, and related traits.

The paper identifies daily oscillating transcripts in the hippocampus of control and epileptic mice, showing distinct circadian patterns and implications for drug timing.

The paper shows that cold exposure causes chromatin compaction and nuclear retention of circadian clock transcripts, which resets the circadian rhythm upon rewarming.

This study identifies DMH leptin receptor-expressing neurons as critical for regulating circadian rhythms in feeding and metabolism in mice.

The paper develops a mathematical model to explain how eS6 phosphorylation integrates circadian and diel signals to detect daylength changes.

MOSAIC improves circadian rhythm detection in proteomic data by integrating transcriptomic information, outperforming existing methods and revealing non-circadian trends.

This study shows that Bmal1 deletion in striatal neurons affects alcohol intake differently in male and female mice, with males showing increased intake and females decreased intake.

The paper analyzes the robustness of oscillations in a circadian clock model by modifying parameter constraints and feedback loops to achieve realistic biological parameters.

The paper identifies cones as an autonomous oscillator in the retinal network and shows they provide input to the master clock under constant light.

The paper investigates the role of melanopsin retinal ganglion cells (mRGCs) in visual and cognitive brain responses in LHON patients using fMRI under different light conditions.

This study uses mathematical models to show that coupling transcriptional and post-translational controls via feed-forward loops improves circadian oscillator robustness against basal leakage.

This study identifies the circadian clock mechanism in mammals that drives seasonal responses to photoperiod changes through BMAL2 and EYA3/TSH pathways.

The paper develops a 12-gene circadian biomarker from epidermal samples that accurately estimates circadian phase across body sites, ages, sexes, and platforms.