Circadian rhythm and melatonin

The paper shows that network communication is important for Drosophila circadian rhythms, with specific neuron groups relying on it for period determination.

The paper constructs a computational model of the mammalian renal circadian clock and validates it against experimental data to understand its role in blood pressure regulation.

The paper identifies a light-mediated pathway in Drosophila that uses PDF-releasing lLNv neurons to adjust circadian rhythms to long day conditions.

This study identifies MAX as a repressive component of the circadian clock core network, essential for maintaining circadian rhythms and balancing molecular clock elements.

The paper shows that weak coupling between feedback loops in circadian clocks leads to dissociated gene expression dynamics at the single-cell level.

The paper characterizes the morphological and physiological properties of three ipRGC subtypes during postnatal development and finds they reach adult-like features at different times.

The paper examines how circadian rhythms influence coordination dynamics and biological functions, finding that circadian effects are consistent across day-night cycles and that disruptions may lead to physical complications.

The paper reanalyses existing data to confirm that melanopsin-weighted quantities improve pupil size modeling using Watson & Yellott's formula.

This study infers coupling and non-linear dynamics between circadian clocks and cell cycles from single-cell microscopy data, revealing temperature-independent, evolutionarily conserved phase-locked states.

ECHO detects and analyzes oscillators in time-course genome-scale data, revealing metabolic regulation through circadian rhythms with changing amplitudes.

The paper investigates circadian oscillations in breast cancer cells using luciferase reporter lines, finding persistent oscillations in low-grade MCF7 cells but not in high-grade MDA-MB-231 cells.

This study identifies miR-210 as a regulator of evening circadian behavior in fruit flies by repressing Fasciclin 2.

The paper identifies a new subtype of pineal projection neurons in zebrafish that express melanopsin and share developmental features with classical projection neurons.

The paper shows that a specific subpopulation of ipRGCs projecting to the SCN mediates light's acute effects on body temperature and sleep, while other ipRGCs are involved in circadian regulation.

This study demonstrates that melanopsin-expressing ganglion cells in fetal mouse retinas are light-responsive and identify the transduction pathways involved.

This study identifies nuclear and plasmotype quantitative trait loci influencing circadian clock robustness to high temperature in wild barley using a doubled haploid population.

The paper develops a mathematical model of the Neurospora crassa circadian clock to elucidate the mechanism of rhythms production and glucose compensation.

The paper shows mammalian Cryptochromes inhibit CRL4Cop1 complex assembly, similar to their function in plants, by interacting with Det1 to repress GR transcription.

Simphony simulates large-scale rhythmic data for benchmarking methods, allowing users to specify experimental designs and feature properties.

The paper develops a computational model to explain mitochondrial Prx/Srx redox oscillations in mammalian tissues, showing that delayed feedback and switches generate robust 24-hour rhythms.

This study examines lactate metabolism in the medial prefrontal cortex of aged and circadian desynchronized mice, finding disruptions in circadian rhythms and gene expression related to neurometabolism.

This study shows CNOT1 enhances phosphorylation of CLOCK and BMAL1 via PKA, stabilizing them and inhibiting their transcriptional activity in the mammalian circadian clock.

This study shows that light-evoked attraction/avoidance behaviors in mosquitoes are circadian and vary between day- and night-biting species.

This study identifies circadian-regulated miRNA-mRNA interactions in Drosophila using CLEAR-CLIP, revealing functional roles of specific miRNAs in circadian control.

This study shows that Shank3 modulates sleep and circadian transcription factor expression in mice, with sleep deprivation exacerbating gene expression differences between Shank3 mutants and wild types.

The paper identifies a circadian pathway in Drosophila where morning and evening oscillators drive pre-motor centers via specific dopaminergic neurons, resulting in a two-peak locomotor activity pattern.

The paper develops bioluminescence reporter lines in Nannochloropsis species to study circadian rhythms and identifies a circadian oscillator in stramenopiles.

The paper shows XBP1s regulates 12h-transcriptome rhythms in liver, aligning with central dogma information flow, and identifies GABP as a novel regulator.

The paper shows BMAL1 DNA binding is tissue-specific and regulates rhythmic transcription through enhancer-enhancer interactions in the mouse liver.

This study identifies hnRNP K as a transcriptional amplifier of DBP, regulating circadian rhythms through chromatin accessibility and mRNA stabilization in Drosophila.