Circadian rhythm and melatonin

The paper shows that social and environmental cues mask circadian activity patterns in shell-dwelling cichlid fish, revealing new relationships between circadian rhythms and sociality.

The paper identifies genetic variants associated with lunar-regulated spawning time in grass puffer fish by analyzing geographic differences in spawning timing and conducting population genomics.

The paper develops an age-corrected model to predict pupil diameter from melanopic equivalent daylight illuminance in real-world conditions, showing it performs well compared to other models.

This study shows that disrupting clock proteins in cockroaches does not eliminate circadian rhythms, suggesting compensatory mechanisms and supporting a model of coupled transcriptional-translational and posttranslational feedback loops.

The paper analyzes daily gene expression rhythms in the regenerating colon using single-cell transcriptomics, revealing cell-type specific patterns and identifying a resource for future studies.

The paper develops a physics-inspired digital twin of the cell using a multi-clock port-Hamiltonian neural network trained on multi-omic circadian data, showing aggregate phase lag agreement but no per-gene correlation.

The paper analyzes circadian gene expression amplitude across multiple human tissues and finds that global transcriptional amplitude varies by individual and tissue, but is not strongly correlated with core clock gene metrics.

This study shows that different mood dimensions are linked to light exposure over distinct timescales in healthy adults under naturalistic conditions.

This study shows that viral replication byproducts called cbVGs drive changes in circadian gene expression during infection through distinct immune pathways, with ARNTL2 playing a key role in amplifying antiviral responses.

This study identifies Drosophila orthologues of OCA-associated genes that regulate sleep and circadian rhythm through visual neurotransmission without affecting pigmentation.

This study identifies ACSF3 as a diurnal regulator of lysine-malonylation and hepatic metabolism, showing its rhythmic expression and role in glycogen storage, lipogenesis, and triglyceride synthesis.

The paper quantifies melanopic input from natural scenes across different environments and photoreceptors, finding structured spatial variation and power-law patterns in melanopic luminance.

ThermoClock is an automated temperature control system that models circadian entrainment and disruption in 2D and 3D in vitro models, showing that ramp time and cycle duration affect rhythm strength and wound healing.

This study identifies circadian regulation of intestinal epithelial cell differentiation through NOTCH/Hes1 oscillations in mouse enteroids.

This study shows that circadian phase modulates visual information transmission in the mouse thalamus, enhancing coding efficiency under high-contrast conditions at night.

This study shows that Nocturnin regulates mitochondrial NADP(H)/NAD(H) rhythms, affecting steroid rhythm amplitude and hepatic metabolism in mice.

This study shows that housing mice in thermoneutrality alters tissue-specific circadian gene expression without changing core clock genes.

This study shows that wild-type Huntingtin regulates neuropeptide trafficking, neuronal excitability, and circadian rhythms in Drosophila, with loss of function causing sleep disturbances and disrupted vesicle dynamics.

This study identifies eight small-molecule enhancers of circadian rhythm amplitude in both central and peripheral clocks through a drug repurposing screen and ex vivo validation.

Heat shock, dexamethasone and osmotic stress all entrain the clock of primary mouse chondrocytes but yield distinct rhythmic transcriptomes, overlapping only marginally with each other and in vivo cartilage.

This study shows that circadian disruption in rats alters the rhythmic expression of clock and memory genes in the hippocampus without changing overall expression levels.

This study shows that the fat body CLOCK in Drosophila suppresses inflammation and extends lifespan under dietary stress, with CLK having a unique role distinct from CYC.

The paper identifies Pde10a as a regulator of neuronal excitability in SCN neurons, showing its rhythmic expression drives a depolarized silent state.

This study investigates how circadian rhythms affect macrophage responses to SARS-CoV-2 spike proteins, finding that timing of exposure leads to distinct immunometabolic states.

The paper uses live-cell imaging to monitor circadian rhythms in Synechocystis cells without reporters, finding no circadian gating of cell division but rhythmic changes in refractive index.

The paper shows that peroxisomal protein import in Drosophila cortex glia is circadian and affects sleep and lipid metabolism, with Pex5 playing a key role.

The paper infers circadian phase from blood biomarkers in UK Biobank using machine learning and defines a new construct, circadian acceleration, with genetic and environmental associations.

The paper identifies a specific dopamine neuron population in mice required for anticipatory locomotion during food anticipation, showing genetic dissociation of behavioral components.

This study uses single-cell RNA sequencing to show that circadian clocks are aligned across liver cell populations and identifies cell-specific circadian regulated pathways.