Hematopoietic Stem Cell Transplantation

This study investigates the role of DOT1L in hematopoietic progenitor cells by analyzing transcriptomes of knockout and mutant models, revealing its function as a transcriptional repressor.

This study shows that DOT1L methyltransferase activity is essential for early murine hematopoiesis, as its loss causes embryonic lethality and genomic instability in hematopoietic progenitors.

The paper identifies Notch glycosylation and Mycn upregulation as critical for endothelial-to-hematopoietic transition during HSC development.

The paper investigates HSC division patterns in mice, finding most divisions are symmetric self-renewing, maintaining HSC output despite age-related decline in differentiation.

The paper shows that MTG16-dependent repression of E protein activity is essential for lymphopoiesis but not myelopoiesis or stem cell functions, using mouse models and functional assays.

This study identifies cell cycle regulation as a driver of endothelial-to-haematopoietic transition using single-cell transcriptomics in a human pluripotent stem cell system.

The paper identifies AGT gene down-regulation in MSCs of paediatric aplastic anaemia patients through gene expression profiling and suggests its potential as a diagnostic marker.

The paper develops small molecule inhibitors of MEIS1 that modulate HSC activity and show efficacy in vitro and in vivo.

The paper identifies a pre-hematopoietic (pre-HE) stage in mouse embryos and shows RUNX1 regulates the transition to hemogenic endothelium, leading to distinct HSPC populations in intra-arterial clusters.

This study demonstrates that cell-free DNA analysis can detect multiple post-transplant complications in HCT recipients through methylation, metagenomic, and genomic profiling.

This study shows that deleting Setd4 in adult mice improves survival from bone marrow failure by enhancing the bone marrow niche and making hematopoietic stem cells more sensitive to radiation.

The paper identifies HSC-primed hemogenic endothelial cells in mouse embryos using single-cell transcriptomics and functional validation, revealing their developmental trajectory and bi-potential.

The paper shows that Dll4 inhibits cell recruitment into aortic clusters, reducing hematopoietic stem cell formation.

The paper identifies CD44 as a marker and regulator of haematopoietic stem cell development through single-cell transcriptomics and functional experiments.

This study shows that cell-free mRNA reflects BM transcriptional activity and functional changes in response to growth factors and hematopoietic reconstitution.

This study shows that deleting a conserved zebrafish Gata2 enhancer impairs haemogenic endothelium programming and adult haematopoiesis, leading to bone marrow failure and immune defects.

The paper defines the transcriptomes and epigenomes of key developmental stages of HSC ontogeny in mice and constructs transcriptional regulatory networks using computational methods.

The paper shows that mechanical instabilities in the aorta drive the extrusion of haematopoietic stem/progenitor cells during embryogenesis through collective endothelial cell migration.

This study shows that GATA2 and GATA3 in trophoblast giant cells regulate hematopoietic-angiogenic balance in the placenta through paracrine signaling.

The paper compares single-cell RNA sequencing data from Yolk Sac and AGM in mouse embryos to identify differences in hematopoietic potential and cell populations.

The paper uses single-cell RNA sequencing to trace the emergence of hematopoietic stem cells in human embryos, identifying key gene expression patterns and cell populations involved in their development.

This study shows glucocorticoids expand immature CFU-E cells in peripheral blood but not cord blood, with p57Kip2 playing a key role in this effect.

This study shows that DPY30, an epigenetic modulator, controls hematopoietic stem cell function by regulating energy metabolism and genome integrity through H3K4 methylation.

This study shows that CHK1 is essential for hematopoietic stem cell survival and fetal hematopoiesis, and that its inhibition causes severe DNA damage and prevents HSC expansion.

The paper uses single-cell transcriptomics to map hematopoiesis in human fetal liver, identifying cell differentiation trajectories and shifts in hematopoietic composition during development.

This study investigates the dose-dependent role of Gfi1 in murine hematopoietic stem cell self-renewal and differentiation, finding that reduced Gfi1 levels impair myeloid and lymphoid differentiation.

The paper identifies lncRNA Spehd as essential for hematopoietic stem cell differentiation and multilineage potential in mice.

This study develops an in-silico model to explore how hematopoietic stem cells (HSCs) respond to varying demands and aging, showing that internal feedback between HSCs and progenitors explains homeostasis and aging-related changes.

GRIMM improves HLA genotype matching efficiency using a graph database, achieving faster runtime and agreement with consensus outputs on a validation dataset.

This study maps clonal lineage commitment pathways of hematopoietic stem cells in vivo, revealing differences in clonal behavior under homeostasis and after hematopoietic depletion.