Hematopoietic Stem Cell Transplantation

Recipient-driven metabolic and epigenetic remodeling of donor hematopoietic cells after transplantation in Fanconi Anemia.

This study shows that the FA recipient environment after HCT causes metabolic, redox, and epigenetic changes in donor-derived hematopoietic cells, even when donor chimerism is stable.

An aged human bone marrow mesenchymal niche causes impaired function of human hematopoietic stem cells under regeneration-induced stress

This study shows that aged human bone marrow mesenchymal stromal cells impair hematopoietic stem cell function under regeneration stress by promoting myeloid bias.

Modeling competitive transplantation using HLA-mismatched human hematopoietic stem cells

This paper introduces a competitive transplantation method using HLA-mismatched human hematopoietic stem cells in humanized mice to study repopulating capacity and track graft dynamics.

Early hematopoietic fate decisions are independent of bone marrow niche

This study shows that early hematopoietic fate decisions are not strongly influenced by bone marrow niche identity, as fate-shaping signals are redundantly provided across niches.

Cell surface ribosomal RNA remodeling regulates hematopoietic stem cell trafficking

This study identifies cationic agents that regulate hematopoietic stem cell trafficking by remodeling cell surface ribosomal RNA, showing bidirectional control over migration and engraftment.

A Novel Role for FSTL-1 in Hematopoietic Stem Cell Homeostasis and Post-injury Regeneration

This study identifies FSTL-1 as a regulator of HSC homeostasis and recovery from bone marrow injury, showing its role in metabolic pathways and cell proliferation.

A genetic anemia disentangles the dual effect of chronically reduced thrombopoietin on hematopoietic stem cells and bone marrow niche

This study uses a genetic anemia model to show that reduced thrombopoietin affects hematopoietic stem cells and the bone marrow niche through direct and indirect mechanisms.

BRM preserves sinusoidal niche resilience through Jag2-Notch signaling during hematopoietic regeneration and aging

This study identifies BRM as a critical regulator of bone marrow sinusoidal niche integrity and hematopoietic regeneration, showing that its decline with age contributes to niche dysfunction and hematopoietic aging.

Single-Cell Behavioromics Enables Fate Prediction of Individual Hematopoietic Stem Cells

This study uses behavioromic analysis to predict hematopoietic stem cell fate with high accuracy and identifies Activin signaling's role in cell behavior and fate.

Glutathione Protects Hematopoietic Stem Cells from Proteotoxic Stress

This study shows that glutathione is essential for proteostasis in hematopoietic stem cells but not for ferroptosis prevention.

In situ identification of pre-hematopoietic stem cells and their niche

The paper identifies pre-hematopoietic stem cells and their niche using spatial transcriptomics in the AGM region, revealing spatial signaling patterns and cellular interactions that support HSC development.

Transforming clinical apheresis waste into a renewable source of patient-derived CD34+ hematopoietic stem cell biobank for beta-hemoglobinopathy research and therapeutic discovery

This paper describes a method to recover and biobank CD34+ hematopoietic stem cells from clinical apheresis waste for hemoglobinopathy research, showing comparable yields and viability to peripheral blood samples.

Dishevelled 2 coordinates aortic Notch signaling through primitive myeloid and hemogenic endothelial cells during hematopoietic stem cell specification

This study identifies Dishevelled 2 as a regulator of HSC specification in zebrafish by coordinating Notch signaling and immune cell support during the endothelial-to-hematopoietic transition.

Stem cell factor acts locally in the bone marrow to promote stem and progenitor cell maintenance

This study shows that SCF produced locally in bone marrow stromal and endothelial cells supports hematopoietic stem and progenitor cell maintenance, while systemic SCF does not.

Kainate receptors coordinate primitive hematopoiesis and hemogenic niche organization to promote hematopoietic stem cell development

This study identifies kainate receptors' role in coordinating primitive hematopoiesis and hemogenic niche organization in zebrafish, showing their impact on hematopoietic stem cell development through endothelial Notch signaling.

Spatially distributed growth factor environments for evaluating hydrogel-based CD34+ cell culture conditions

This paper presents a microfluidic system to create spatial growth factor gradients in hydrogels for studying CD34+ cell behavior and optimizing culture conditions.

Scalable expansion of human iNKT cells: single-cell profiling and in vivo control of GvHD with preserved GvL activity

This paper develops a scalable method to expand human CD4- iNKT cells from PBMCs using IL-15 and -GalCer, showing improved GVHD control and GVL activity in preclinical models.

Intravital microscopy and statistical image analysis of early engraftment of haematopoietic stem cells reveal dynamic and evolving cellular behaviours linked to progressive differentiation.

The paper uses intravital microscopy and statistical image analysis to study early HSC engraftment, revealing dynamic cellular behaviors linked to differentiation over time.

The Pentose Phosphate Pathway Regulates Myelo-Lymphoid Lineage Specification

This study identifies the pentose phosphate pathway's role in regulating myeloid versus lymphoid lineage specification in hematopoietic stem and progenitor cells through metabolic state-fate mapping.

Midbody inheritance predicts re-entry into quiescence, but not lineage potential, in mouse hematopoietic stem cells

This study shows midbody inheritance in HSCs delays re-entry into the next cell cycle but does not affect lineage potential.

Modelling human haematopoietic stem cell commitment ex vivo identifies IL-33 as a regulator of megakaryopoiesis

The paper introduces an EPD assay to study human HSC lineage commitment and identifies IL-33 as a regulator of megakaryopoiesis by activating the MAPK pathway.

Neogenin-1 marks myeloid-primed fetal hematopoietic stem cells that undergo progressive lineage-restriction with age

The paper identifies Neogenin-1 as a marker for myeloid-biased fetal HSCs and shows that lineage bias is established early and reinforced with age.

Transient reprogramming limits AP-1-associated chromatin opening and transposable element activation to preserve hematopoietic stem cell function during aging and stress

This study shows that transient reprogramming with Yamanaka factors delays and partially reverses HSC aging and stress-induced decline by limiting AP-1 chromatin opening and transposable element activation.

Perturb-seq identifies co-regulated gene programs shaping hematopoietic stem and progenitor cell function

This study uses Perturb-seq to identify gene regulatory programs in HSPCs that link genetic regulators to cell biological processes and stem cell phenotypes.

Cesium-137 and X-Ray Irradiation Yield Comparable Immune Phenotypes and Activation States in Bone Marrow Chimeric Studies

This study compares immune phenotypes and activation states in bone marrow chimeras after irradiation with cesium-137 or X-ray sources, finding no significant differences.

Inflammatory restraint and membrane lipid integrity protect hematopoietic stem cells under stress

This study shows that THPO protects HSCs from inflammatory stress by maintaining membrane lipid integrity and suppressing STAT1-driven pyroptosis.

Dll4 and Jag1a signalling act sequentially and cooperatively to drive hematopoietic stem cell fate specification

This study shows Dll4 and Jag1a sequentially and cooperatively regulate hematopoietic stem cell fate by modulating MAPK signaling and shear stress during endothelial-to-hematopoietic transition.

GRIMM-II: A Two-Stage Real-Time Algorithm for Nine-Locus HLA Imputation and Matching with Up to Three Mismatches

GRIMM-II improves HLA donor matching by imputing nine loci and identifying donors with up to three mismatches in real-time.

Locus-specific transposable element expression drives human hematopoietic stem cell disease pathophysiology

This study identifies locus-specific transposable elements driving VEXAS syndrome pathophysiology by regulating myeloid commitment in UBA1-mutant hematopoietic stem cells.

Chromatin Accessibility Shapes Developmental-Specific Lineage Plasticity in Hematopoiesis

The paper shows fetal hematopoietic stem and progenitor cells (HSPCs) have greater lineage plasticity than adult HSPCs, linked to chromatin accessibility differences.