Reproductive Biology and Fertility

This study shows that apoptosis in C. elegans maintains germline structure and fertility by preventing morphological defects and ensuring proper oocyte development.

This study screens compounds to identify those that block meiotic progression in mouse oocytes, offering potential non-hormonal contraceptive candidates.

The paper investigates the association between maternal age and meiotic recombination failure with triploid/haploid conceptions in humans, identifying a maternal age effect and new types of genome-wide maternal isodiploidy.

This study analyzes ovarian aging across species using single-cell RNA-seq data to identify conserved and species-specific features and suggests drug repurposing candidates.

This study shows that in vitro fertilization (IVF) accelerates reproductive aging in female mice by causing premature ovarian failure, with altered ovarian function and epigenetic changes.

This study compares human and mouse ovarian biology across age using 3D-imaging, single-cell transcriptomics, and functional studies, identifying species-specific and age-related changes in follicle dynamics and gene expression.

This study optimizes vitrification protocols to enhance the preservation of ex vivo 3D tumor models, achieving high proliferative capacity retention.

This study identifies a mechanical defect in embryos from aged mothers that impairs implantation, showing increased trophectoderm contractility leads to defective spreading during implantation.

This study shows that ovarian cellular diversity arises from spatially organized, transcriptionally heterogeneous coelomic epithelium progenitors in fetal mouse and human ovaries, which are primed toward supporting or steroidogenic identities.

This study examines the transcriptomic and proteomic changes in cultured ovarian follicles, identifying gene expression patterns and differentially expressed genes between group culture conditions.

The paper investigates the spatiotemporal dynamics of lumen formation in mammalian follicles, revealing a critical phenomenon involving fluid networks and cell death.

This paper introduces an AI system that forecasts future embryo morphology in time-lapse videos using Convolutional LSTM layers, showing accurate predictions for cleavage and blastocyst stages.

This study investigates oogenesis defects in Dyro mutant Drosophila melanogaster, identifying nuclear abnormalities and protein aggregation in nurse cells as key factors in female sterility.

This study shows that ergothioneine and a nutraceutical formula protect against cyclophosphamide-induced premature ovarian failure in rats by reducing oxidative stress and inflammation.

The paper investigates the cell and molecular origins of the primate ovarian reserve using rhesus macaques, identifying PG2 cells as the primary source of primordial follicles and describing the recruitment of fetal theca cells for hormone production.

This study develops a protocol to induce high-yield ovulation in adult fat-tailed dunnarts using estrus synchronization and PMSG-hCG treatment, resulting in a high number of mature MII oocytes.

The paper describes a method for culturing postnatal mouse ovaries on membrane inserts to study primordial follicle dynamics and demonstrates its impact on follicle count.

The paper identifies a fusome in mouse germline cysts that mediates oocyte development by establishing polarity and asymmetric distribution of cellular components.

This study shows that full-length BEND2 is not needed for male fertility but is essential for establishing the ovarian reserve in mice.

The paper shows that chromosome ageing, marked by increased chromatid separation and cohesin depletion, occurs in primordial follicles in both mouse and human oocytes.

This study uses phosphoproteomics to analyze protein phosphorylation during Xenopus oocyte meiotic divisions, revealing key phosphorylation events and their roles in meiotic processes.

This study analyzes proteostasis in human oocytes, finding reduced degradative activity and mitochondrial membrane potential during maturation, suggesting preserved cellular components.

This study shows that Thioredoxin-1 prevents granulosa cell ferroptosis by promoting mitophagy, thereby improving ovarian aging and fertility in mice.

This systematic review summarizes evidence on heat stress's adverse effects on mammalian oocytes and ovaries, highlighting impaired function and reduced quality.

This study shows that non-growing oocytes in mice have pre-established epigenetic marks that prime the epigenome for oocyte maturation and early embryogenesis, challenging the traditional view that these marks are acquired after ovarian reserve exit.

The paper analyzes single-oocyte RNA sequencing data from early-stage human follicles to identify differentially expressed genes between primordial and transitioning stages.

This study maps the spatiotemporal profile of ovulation in mice using single-cell RNA-seq and spatial transcriptomics, identifying cell state markers and interactions involved in the process.

This study identifies multinucleated giant cells (MNGCs) in aging ovaries, showing their unique immune and degradation-related molecular signatures through transcriptomic and imaging analyses.

This study identifies a variant in PARP1 associated with earlier menopause by affecting primordial germ cell fate through altered DNA binding and transcriptional regulation.

This study systematically compares three mouse menopause models to identify shared and model-specific features of follicle loss and endocrine disruption using single-cell transcriptomics and machine learning.