Cannabis and Cannabinoid Research

Sex-dependent endocannabinoid adaptations in supraspinal pain modulatory circuits after peripheral nerve injury

This study identifies sex-dependent changes in endocannabinoid signaling in pain-modulatory brain regions following nerve injury in rats.

Psychopharmacological Effects of Cannabidiol in Rodent Models of Autism Spectrum Disorder: A Systematic Review of Behavioral Outcomes, Neurobiological Mechanisms, and Methodological Quality

This review evaluates CBD's effects on rodent ASD models, finding beneficial behavioral and neurobiological outcomes but highlighting methodological limitations.

Efficacy profiling of structurally diverse cannabinoid receptor ligands across transducer-coupling assays

The paper profiles the efficacy of 22 cannabinoid ligands at CB1 and CB2 receptors using BRET assays, finding consistent trends in agonist efficacy and antagonist effects.

Cannabis THC:CBD Composition Affects Oligodendrocyte Progenitor Cell Characteristics Following Acute Cannabis Vapor Inhalation in Adult Male and Female Mice

This study examines how different cannabis THC:CBD compositions affect oligodendrocyte progenitor cells in mice after acute vapor inhalation, finding morphological and mitochondrial changes similar to early differentiation.

Morphine causes distinct changes in the lipidome throughout the brain and body after acute or chronic administration: implications for novel endogenous lipid signaling systems involved in opioid reward and withdrawal

This study examines how morphine alters lipid levels in different brain and body regions after acute or chronic administration, identifying potential endogenous lipid signaling systems involved in opioid reward and withdrawal.

A phytocannabinoid-sensitive phosphorylation switch converts endocannabinoids into alternative lipid GPCR activators

The paper shows that phosphorylation of anandamide by DGKQ converts it into AEAp, which acts as a ligand for LPARs and MRGPRX4, linking eCB metabolism to Cannabis pharmacology.

Beta-caryophyllene restores blood pressure, heart rate, and electrocardiographic alterations while mitigating cardiometabolic biomarkers in a rat model of metabolic syndrome: Implications for non-communicable disease prevention.

This study shows Beta-caryophyllene reduces blood pressure, heart rate, and inflammation in a rat model of metabolic syndrome, suggesting it could be a low-cost preventive strategy for non-communicable diseases.

An endocannabinoid-nitric oxide signaling switch triggers reciprocal inhibitory-excitatory plasticity at dopamine neuron inputs following prenatal cannabinoid exposure

This study investigates how prenatal cannabinoid exposure affects endocannabinoid-mediated synaptic plasticity in dopamine neurons, revealing a switch to nitric oxide signaling that alters excitatory and inhibitory plasticity.

Integrated pharmacological and structural profiling reveals CB1 residue interaction patterns associated with synthetic cannabinoid receptor agonist efficacy

The paper analyzes the pharmacological and structural features of synthetic cannabinoid receptor agonists to identify receptor interaction patterns linked to their efficacy.

Restoration of circulating 2-arachidonoylglycerol levels attenuates cocaine self-administration through endocannabinoid-dopamine interactions in common marmosets

This study shows that restoring 2-AG levels reduces cocaine self-administration in marmosets by modulating dopamine and GPR55/DAT interactions.

Chronic {triangleup}9-Tetrahydrocannabinol Vapor Self-Administration Modulates Gut Microbiota and the Immune and Endocannabinoid Systems in Female Sprague-Dawley Rats

This study shows chronic THC vapor exposure in rats affects brain endocannabinoid and immune systems but not peripheral organs, leading to gut microbiota changes and altered metabolites.

Endocannabinoid-dopamine interactions mediate incidental associations in the hippocampus

This study investigates how endocannabinoid-dopamine interactions in the hippocampus mediate incidental associations, showing that CB1 receptors in D1-receptor-expressing cells are critical for IA formation.

Nociceptor-restricted cannabinoid receptor 1 contributes to chronic but not acute analgesia

The paper investigates the role of cannabinoid receptor 1 (CB1R) in pain modulation by selectively reactivating it in peripheral sensory neurons, finding it contributes to chronic but not acute analgesia.

Glucocorticoid - endocannabinoid crosstalk in the ventrolateral periaqueductal gray (vlPAG) promotes pain resolution

The paper shows that glucocorticoid-endocannabinoid interactions in the vlPAG promote pain resolution but require careful management to avoid receptor desensitization.

Sex-specific effects of prenatal delta-9-tetrahydrocannabinol exposure on repetitive behavior and prefrontal cortex neuronal excitability in preadolescent rats

This study shows that prenatal THC exposure affects repetitive behavior and PFC neuronal excitability in male rats, with no change in dopamine transmission but altered gene expression and sex differences in Netrin-1.

Impact of Δ9-tetrahydrocannabinol and oxycodone co-administration on measures of antinociception, dependence, circadian activity, and reward in mice

This study examines how combining Δ9-THC and oxycodone affects pain relief, dependence, circadian activity, and reward in mice, finding enhanced antinociception without increased dependence but with increased reward.

Selective GRAB sensors reveal distinct endocannabinoid dynamics in vivo

The paper develops selective fluorescent sensors to detect endocannabinoid dynamics in vivo and shows that Δ9-THC induces sustained 2-AG signaling in the nucleus accumbens.

Antinociceptive properties of an oral formulation of Δ9-tetrahydrocannabinol in aqueous 2-hydroxypropyl-β-cyclodextrin in female rats

This study evaluates the antinociceptive effects of an oral THC/HPβCD formulation in female rats, showing efficacy at higher doses with some tolerance after chronic use.

Sex-specific differences in endocannabinoid regulation of cocaine-evoked dopamine in the medial nucleus accumbens shell

The paper investigates sex-specific differences in endocannabinoid regulation of cocaine-evoked dopamine in rats, finding females show enhanced sensitivity to CB1R and 2-AG effects.

Sex-Dependent Modulation of Emotional and Cognitive Processes by Prefrontal CB1 Receptors

This study investigates how CB1 receptor deletion in prefrontal GABAergic neurons affects emotional and cognitive processes differently in male and female mice.

Endocannabinoid ligands (CBD, Δ9THC, and Terpenes) inhibit excitability of mouse dorsal root ganglion neurons and exhibit synergistic inhibitory effects

This study shows that CBD, THC, and terpenes inhibit mouse DRG neuron excitability, with synergistic effects suggesting potential for non-opioid analgesics.

Glycosylation of anandamide and other bioactive N-acylethanolamines in mammalian cells and tissues

The paper identifies NAE glycosylation as a metabolic pathway that links endocannabinoid metabolism to lysosomal dysfunction and inflammation.

Distinct Glutamatergic Inputs to the Nucleus Accumbens Differentially Regulate Vulnerability to Cannabinoid Addiction

This study investigates how two glutamatergic pathways to the nucleus accumbens influence vulnerability to cannabinoid addiction in mice, finding that both increase persistence of drug seeking but affect other behaviors differently.

Antagonistic activity of AEA on TAT treated Human Astrocytes identify Inflammaging pathways

This study investigates how Anandamide affects microRNA expression in HIV1 TAT-stimulated human astrocytes, identifying miRNAs involved in anti-inflammatory pathways.

Cannabinoid CB2 receptor activation drives glucose uptake, shifting T cell metabolism.

This paper shows that CB2R activation in T cells increases glucose uptake and shifts metabolism toward oxidative phosphorylation and the pentose phosphate pathway, with effects dependent on the receptor.

Endothelial cannabinoid CB1 receptor deficiency reduces arterial inflammation and lipid uptake in response to atheroprone shear stress

This paper shows that blocking endothelial CB1 receptors reduces arterial inflammation and lipid uptake under atheroprone shear stress, suggesting potential therapeutic benefits for atherosclerosis.

Preserved Barrier Integrity and Altered Immune Profiles in Chronic Cannabis Users: Potential Roles of Δ9-Tetrahydrocannabinol

This study shows chronic cannabis use strengthens gut barrier integrity but disrupts systemic immune homeostasis through cytokine dysregulation.

Selection of potent biologic antagonists of the cannabinoid GPCR CB2R from a constrained peptide library

The paper identifies potent CB2R antagonists from a peptide library that inhibit gut homing in a mouse model of Crohn's disease.

Prenatal Cannabidiol and Δ9-Tetrahydrocannabinol exposure lead to sex-specific disruptions in risk assessment and behavioral switching via divergent rewiring of the adult mPFC

This study examines sex-specific effects of prenatal CBD and THC exposure on adult mouse behavior and prefrontal cortex circuitry, revealing distinct synaptic and behavioral outcomes.

Dimethylindanoylindole isomers revealed different pharmacological profiles at CB1 and CB2 cannabinoid receptors

The paper compares pharmacological profiles of dimethylindanoylindole isomers at CB1 and CB2 receptors using BRET assays and site-directed mutagenesis.