Cannabis and Cannabinoid Research

The paper shows that glucocorticoid-endocannabinoid interactions in the vlPAG promote pain resolution but require careful management to avoid receptor desensitization.

This study examines how combining Δ9-THC and oxycodone affects pain relief, dependence, circadian activity, and reward in mice, finding enhanced antinociception without increased dependence but with increased reward.

The paper investigates sex-specific differences in endocannabinoid regulation of cocaine-evoked dopamine in rats, finding females show enhanced sensitivity to CB1R and 2-AG effects.

This study investigates how Anandamide affects microRNA expression in HIV1 TAT-stimulated human astrocytes, identifying miRNAs involved in anti-inflammatory pathways.

This paper shows that blocking endothelial CB1 receptors reduces arterial inflammation and lipid uptake under atheroprone shear stress, suggesting potential therapeutic benefits for atherosclerosis.

The paper compares pharmacological profiles of dimethylindanoylindole isomers at CB1 and CB2 receptors using BRET assays and site-directed mutagenesis.

This study examines the relationship between cannabis use, glutamate levels in the anterior cingulate cortex, and symptom severity across the psychosis spectrum using 7T proton magnetic resonance spectroscopy.

This study shows CBD increases classical HLA-C and decreases non-classical HLA-G in JEG-3 cells via distinct receptor and calcium-dependent pathways.

The paper presents a systems-level analysis of the endocannabinoid system (ECS) using network integration, identifying hubs, communities, and resilience mechanisms.

The paper examines how four minor cannabinoids modulate sensory neuron activation in mouse DRG neurons, revealing distinct activation patterns and dose-response relationships.

The paper examines how cannabis use onset and THC/CBD exposure affect neurocognitive trajectories in adolescents using longitudinal data from the ABCD Study.

This study finds that daily cannabis use in people with HIV is linked to an anti-inflammatory immunometabolic phenotype in macrophages, associated with reduced neurocognitive deficits.

This study investigates the biophysical mechanisms underlying anandamide selectivity for CB1 receptors, revealing enthalpic and entropic effects shaped by N-terminus movements and binding pocket volume differences.

This study shows that cannabinoid administration alters central amygdala somatostatin neuron activity and network dynamics, affecting threat-related behavior representation.

The paper identifies an optimal cannabinoid-terpene ratio that reduces DCA-induced DNA damage and mutagenicity in esophageal cells and correlates ECS receptor expression with EAC progression.

This study tests three phytocannabinoids' effects on reducing voluntary alcohol consumption in rats, finding that CBN and THCV reduced intake with good safety, while CBD had limited effect and some side effects.

This study identifies structural features of synthetic cannabinoid receptor agonists that confer high-efficacy agonism through bioluminescence resonance energy transfer assays and electrophysiology.

This study examines how adolescent cannabinoid exposure affects ethanol self-administration and naltrexone efficacy in rats, revealing sex-dependent changes in ethanol consumption patterns and response to naltrexone.

This paper introduces two novel CB2-specific agonist antibodies that reduce macrophage activation and fibrosis in vitro and an ex vivo liver model.

This study investigates whether inhaled CBD pretreatment inhibits GBM growth in mice, finding that 14-day pretreatment reduces tumor growth and modulates the immune microenvironment.

This study tests if oral CBD reduces opioid withdrawal symptoms in rats, finding no significant effect on physical or anxiety-like withdrawal symptoms.

This study shows that CBD reduces oxycodone self-administration in rats with neuropathic pain without diminishing oxycodone's pain-relieving effects.

This study shows that repeated CBD administration in rats reduces splenic lymphocyte numbers via CB2 receptors, similar to its effects in peripheral blood.

This study shows that adolescent exposure to a CB1R agonist leads to lasting theta rhythm abnormalities in adulthood, with greater effects when exposure occurs during early adolescence.

This study shows that chronic nicotine pouch exposure worsens seizures and glymphatic function in mice, but inhaled CBD reverses these effects.

The paper introduces fluorescent activity-based probes to map MAGL activity in brain tissues, revealing its spatial distribution in mouse and human brains.

This study examines THC vapor self-administration in rats, finding that pre-exposure to THC increases intake and that females show higher responding under certain conditions.

This study investigates the relationship between the endocannabinoid system and pain sensitivity in humans using quantitative sensory testing, finding no significant associations overall but a specific link between FAAH substrates and pressure pain thresholds.

This study investigates how CB2 receptor ligands influence anterograde trafficking and subcellular distribution, revealing their role as pharmacological chaperones.