Cannabis and Cannabinoid Research

This study identifies sex-dependent changes in endocannabinoid signaling in pain-modulatory brain regions following nerve injury in rats.

This review evaluates CBD's effects on rodent ASD models, finding beneficial behavioral and neurobiological outcomes but highlighting methodological limitations.

The paper profiles the efficacy of 22 cannabinoid ligands at CB1 and CB2 receptors using BRET assays, finding consistent trends in agonist efficacy and antagonist effects.

This study examines how different cannabis THC:CBD compositions affect oligodendrocyte progenitor cells in mice after acute vapor inhalation, finding morphological and mitochondrial changes similar to early differentiation.

This study examines how morphine alters lipid levels in different brain and body regions after acute or chronic administration, identifying potential endogenous lipid signaling systems involved in opioid reward and withdrawal.

The paper shows that phosphorylation of anandamide by DGKQ converts it into AEAp, which acts as a ligand for LPARs and MRGPRX4, linking eCB metabolism to Cannabis pharmacology.

This study shows Beta-caryophyllene reduces blood pressure, heart rate, and inflammation in a rat model of metabolic syndrome, suggesting it could be a low-cost preventive strategy for non-communicable diseases.

This study investigates how prenatal cannabinoid exposure affects endocannabinoid-mediated synaptic plasticity in dopamine neurons, revealing a switch to nitric oxide signaling that alters excitatory and inhibitory plasticity.

The paper analyzes the pharmacological and structural features of synthetic cannabinoid receptor agonists to identify receptor interaction patterns linked to their efficacy.

This study shows that restoring 2-AG levels reduces cocaine self-administration in marmosets by modulating dopamine and GPR55/DAT interactions.

This study shows chronic THC vapor exposure in rats affects brain endocannabinoid and immune systems but not peripheral organs, leading to gut microbiota changes and altered metabolites.

This study investigates how endocannabinoid-dopamine interactions in the hippocampus mediate incidental associations, showing that CB1 receptors in D1-receptor-expressing cells are critical for IA formation.

The paper investigates the role of cannabinoid receptor 1 (CB1R) in pain modulation by selectively reactivating it in peripheral sensory neurons, finding it contributes to chronic but not acute analgesia.

This study shows that prenatal THC exposure affects repetitive behavior and PFC neuronal excitability in male rats, with no change in dopamine transmission but altered gene expression and sex differences in Netrin-1.

The paper develops selective fluorescent sensors to detect endocannabinoid dynamics in vivo and shows that Δ9-THC induces sustained 2-AG signaling in the nucleus accumbens.

This study evaluates the antinociceptive effects of an oral THC/HPβCD formulation in female rats, showing efficacy at higher doses with some tolerance after chronic use.

This study investigates how CB1 receptor deletion in prefrontal GABAergic neurons affects emotional and cognitive processes differently in male and female mice.

This study shows that CBD, THC, and terpenes inhibit mouse DRG neuron excitability, with synergistic effects suggesting potential for non-opioid analgesics.

The paper identifies NAE glycosylation as a metabolic pathway that links endocannabinoid metabolism to lysosomal dysfunction and inflammation.

This study investigates how two glutamatergic pathways to the nucleus accumbens influence vulnerability to cannabinoid addiction in mice, finding that both increase persistence of drug seeking but affect other behaviors differently.

This paper shows that CB2R activation in T cells increases glucose uptake and shifts metabolism toward oxidative phosphorylation and the pentose phosphate pathway, with effects dependent on the receptor.

This study shows chronic cannabis use strengthens gut barrier integrity but disrupts systemic immune homeostasis through cytokine dysregulation.

The paper identifies potent CB2R antagonists from a peptide library that inhibit gut homing in a mouse model of Crohn's disease.

This study examines sex-specific effects of prenatal CBD and THC exposure on adult mouse behavior and prefrontal cortex circuitry, revealing distinct synaptic and behavioral outcomes.

This study links genomic variation to real-time Δ9-THC response in humans, showing associations between CYP3A4 expression and psychotomimetic effects.

This study examines the effects of chronic cannabis vapour exposure and withdrawal on behavioural networks in rats, finding significant reorganization of behavioural dynamics.

This study shows CBD reduces chemotherapy-induced neuropathic pain through NAPE-PLD and PPAR receptor pathways, but not CB1/CB2.

This study investigates the pharmacological activity of (+)-trans-CBD at CB1 and CB2 receptors, finding it acts as a CB2 agonist with higher affinity than (-)-CBD.

The paper identifies sex-specific miRNA signatures in the medial prefrontal cortex associated with cannabinoid addiction-like behavior in female mice.

This study shows that peripheral CB1R inhibition reduces food intake and improves metabolism in obese mice through both vagal-dependent brainstem activation and vagal-independent hypothalamic effects.