Cannabis and Cannabinoid Research

This study examines how adolescent cannabinoid exposure affects ethanol self-administration and naltrexone efficacy in rats, revealing sex-dependent changes in ethanol consumption patterns and response to naltrexone.

This paper introduces two novel CB2-specific agonist antibodies that reduce macrophage activation and fibrosis in vitro and an ex vivo liver model.

This study investigates whether inhaled CBD pretreatment inhibits GBM growth in mice, finding that 14-day pretreatment reduces tumor growth and modulates the immune microenvironment.

This study tests if oral CBD reduces opioid withdrawal symptoms in rats, finding no significant effect on physical or anxiety-like withdrawal symptoms.

This study shows that CBD reduces oxycodone self-administration in rats with neuropathic pain without diminishing oxycodone's pain-relieving effects.

This study uses human iPSC-derived prefrontal cortex organoids to show that THC exposure disrupts neurodevelopmental gene expression and epigenetic regulation, linking these changes to autism risk genes.

This study shows that repeated CBD administration in rats reduces splenic lymphocyte numbers via CB2 receptors, similar to its effects in peripheral blood.

This study shows that FAAH inhibition by URB597 improves memory and alters stress hormone levels differently in male and female rats.

This study investigates the combined effects of (S)-ketamine and THC on behavior and physiology in mice, finding that ketamine enhances THC-induced hypothermia and motor impairments.

This study shows that adolescent exposure to a CB1R agonist leads to lasting theta rhythm abnormalities in adulthood, with greater effects when exposure occurs during early adolescence.

The paper compares the distribution of CB1R, FAAH, and MAGL in human and mouse AD brains, finding species-specific differences that may affect the translatability of ECS findings in mouse models.

This study shows that activating CB1 receptors in zebrafish leads to increased non-axonal ensheathment without affecting OL differentiation or normal myelin formation.

This study shows that chronic nicotine pouch exposure worsens seizures and glymphatic function in mice, but inhaled CBD reverses these effects.

This study shows that CBD reduces excitability of D1 and D2 medium spiny neurons in the nucleus accumbens core without affecting excitatory synaptic transmission.

The paper introduces fluorescent activity-based probes to map MAGL activity in brain tissues, revealing its spatial distribution in mouse and human brains.

This study examines THC vapor self-administration in rats, finding that pre-exposure to THC increases intake and that females show higher responding under certain conditions.

This study investigates the relationship between the endocannabinoid system and pain sensitivity in humans using quantitative sensory testing, finding no significant associations overall but a specific link between FAAH substrates and pressure pain thresholds.

This study shows that Δ9-THC withdrawal increases LHb responsivity to aversive stimuli through impaired synaptic inhibition and altered E-I balance.

This study investigates how CB2 receptor ligands influence anterograde trafficking and subcellular distribution, revealing their role as pharmacological chaperones.

This study examines the behavioral effects of the neutral CB1R antagonist AM6527 in mice, finding dose-dependent reductions in reward consumption and motivated behavior, with partial dopaminergic rescue.

This study shows that an obesogenic diet impairs memory consolidation in mice via the hippocampal endocannabinoid system and mTOR pathway, which can be reversed by CB1R blockade or mTOR inhibition.

This study shows CBD and CBD-HCE reduce HLA-G expression in JEG-3 cells, suggesting a potential immunomodulatory role in cancer therapy.

This study investigates the role of NAPE-PLD in opioid responsiveness and finds sex-dependent differences in oxycodone and sucrose consumption in knockout mice.

This study investigates the antinociceptive effects of CBV and THCV in C. elegans, showing dose-dependent effects and involvement of vanilloid and cannabinoid pathways.

This study shows prenatal exposure to CBD or THC alters adult offspring behavior differently by sex, with CBD increasing female risk assessment and both increasing repetitive behavior.

This study shows high-dose CBD pretreatment reduces opioid-induced persistent apnea in mice, as effective as naloxone, suggesting a new approach to prevent opioid overdose deaths.

This study shows prenatal CBD exposure causes sex-specific anxiety disruptions in mice, with females showing persistent anxiety-like behaviors and altered reward responsiveness.

The study examines how stress and THC affect working memory in rats, finding that high THC doses disrupt motivation in some animals, linked to higher THC concentrations.

This study shows THC protects astrocytes from HIV Tat-induced senescence and inflammation in rhesus macaques, but high-dose THC may harm glial survival.