Muscle Physiology and Disorders

This paper investigates the role of mitochondrial ROS in skeletal muscle atrophy during ovarian cancer and finds that SkQ1 reduces mitochondrial-linked apoptosis but not necroptosis or atrophy.

This study uses R405W desmin knock-in mice to identify mitochondrial dysfunction, protein quality control issues, and myofibrillar structural changes in myofibrillar myopathy.

This study compares transcriptomic profiles of in vitro human skeletal muscle models with in vivo references to identify discrepancies and suggest improvements.

This study shows that reduced RyR1 in muscle spindles of mice with recessive Ryr1 mutations causes proprioception issues and scoliosis.

This study shows that ERRα promotes skeletal muscle regeneration and reduces dystrophy in DMD by enhancing angiogenesis and mitochondrial function.

This study shows that culturing muscle fibers in a 3D hydrogel improves viability and preserves contractile function compared to 2D culture.

This study investigates dystrophin mRNA and protein expression dynamics during muscle repair, revealing post-transcriptional control mechanisms and suggesting degradation as a therapeutic target.

This study shows that blocking ActRIIA/IIB increases muscle mass and strength in mice but causes glucose intolerance and reduced voluntary activity.

This study shows MMP inhibition rescues muscle regeneration in telomerase-deficient zebrafish by improving muscle stem cell migration and function.

This study shows that Site-1 Protease (S1P) negatively regulates sarcolipin expression by inhibiting its promoter activity through ATF6 and CREB binding.

This study identifies a multimodal transcriptional response in denervated skeletal muscle, revealing altered cholesterol homeostasis and its impact on myofiber size.

This study shows that increasing JAG1 expression in dystrophin-deficient mice improves muscle size, strength, and myofiber number.

This study presents a Lama2 knockout mouse model for LAMA2-related muscular dystrophy, analyzing its phenotype, neuropathology, and transcriptomics data to elucidate molecular pathogenesis.

This study shows that oral N-acetylglucosamine improves spontaneous locomotor activity in mdx mice, with combined treatment enhancing effects compared to prednisolone alone.

This study identifies matrisome signatures in quiescent and activated muscle stem cells using transcriptomic data, linking ECM gene expression to niche function and muscle repair.

Voluntary wheel running improves muscle function and reduces tubular aggregates in a mouse model of tubular aggregate myopathy.

This study examines HGF distribution in different muscle fiber types and its nitration during disuse and reloading, finding higher HGF in type IIa/x fibers and increased nitroHGF in disuse.

The paper tracks progenitor populations in avian embryos to reveal distinct lineages of primary and secondary myotubes and their relationship to adult muscle stem cells.

This study shows Klotho deficiency causes skeletal muscle weakness and impaired motor unit connectivity by altering neuromuscular junction structure and function.

This study shows that myosin VI regulates mitochondrial function and energy metabolism in skeletal muscle by affecting respiratory capacity, ATP production, and fiber type composition.

This study shows that POGLUT1 is essential for muscle stem cell development and maintenance in mice, with loss of function leading to muscle defects and impaired repair.

This paper shows that delivering AMPK activator 991 via polymeric nanoparticles reduces toxicity and improves muscle homeostasis in a DMD mouse model.

The paper screens epigenetic small molecules in a zebrafish DMD model to identify SR-4370, a new HDACi that ameliorates muscle degeneration.

This study identifies Dystrophin's role in maintaining myonuclear spacing through its interaction with Msp300 and regulation of microtubule organization during Drosophila myogenesis.

This study identifies changes in the skeletal muscle nuclear proteome after acute exercise, revealing post-transcriptional effects on mRNA processing and splicing.

This study shows that soft elasticity and microgrooves promote the formation of slow-twitch muscle-like myotubes by enhancing fiber-type markers and orientation.

This study examines how combined aerobic and resistance exercise training affects the spatial transcriptome of skeletal muscle in young adults, identifying fiber type-specific gene expression changes and shifts in interstitial cell populations.

This paper establishes bat muscle cell lines and analyzes their transcriptomic and metabolic profiles to study muscle regeneration and flight muscle biology in bats.

This study identifies large MAF transcription factors as inducers of type IIb myofibers in humans, enhancing glycolytic capacity and correlating with power training.