Muscle Physiology and Disorders

This study shows that hyperactivation of TAK1 in adult mice causes skeletal muscle pathology similar to inflammatory myopathies, while low activation improves muscle mass.

This study identifies that immune aging impairs muscle regeneration by altering macrophage-derived antioxidant selenoprotein P expression and function in aged mice.

This study shows microtubules coordinate mitochondria transport and myofibril formation during muscle development in Drosophila and mammals.

This study shows mitochondrial-targeted plastoquinone SkQ1 reduces early muscle weakness in ovarian cancer mice by improving calcium handling and mitochondrial function, without preventing atrophy.

This paper develops a multi-scale machine learning model to predict muscle and functional disease progression in FSHD using MRI and clinical data, achieving strong predictive performance in holdout datasets.

The paper identifies a BMP4-induced molecular signature in late-stage DMD skeletal muscle by comparing transcriptomes of DMD patients and BMP4-stimulated cells.

This study identifies TMEM9B-AS1, a human-specific lncRNA downregulated in type 2 diabetes skeletal muscle, which regulates ribosomal biogenesis by stabilizing MYC mRNA through interaction with IGF2BP1.

This study shows that the D2-mdx mouse model exhibits juvenile-onset cardiac damage due to unresolved inflammation, and pro-resolution therapy can mitigate fibrotic degeneration.

The paper discovers that sarcomeres divide along the myofibril tension axis during Drosophila muscle development to add new sarcomeres while maintaining mechanical integrity.

This study identifies exercise-induced anti-aging processes in skeletal muscle by analyzing intron retention and its link to genomic instability and mitochondrial function.

This study shows that reduced NR4A3 levels in skeletal muscle due to inactivity impair glucose metabolism, translation, and myotube size by affecting mTORC1 and ribosomal pathways.

This study identifies RCOR1 as a positive regulator of myogenesis and skeletal muscle regeneration by interacting with LSD1 and MyoD.

This study identifies early aging-related changes in muscle MERC ultrastructure and proteome, which are reversed by exercise, suggesting potential therapeutic targets for sarcopenia.

This study identifies transcriptional changes in black bears during hibernation that preserve muscle protein content through mTORC1 signaling and BCAA metabolism.

The paper identifies and characterizes quiescent stem cells in a non-human primate, showing their in vivo self-renewal and similarity to human cells.

This study examines age-related changes in serial sarcomere number across five hindlimb muscles in rats at four aging timepoints, finding significant SSN loss contributing to muscle mass decline.

This paper develops a high-resolution kinematic method to quantify impaired mobility in dystrophic zebrafish larvae, finding significant differences in swimming performance between mutants and wild-types.

This study shows PSME3 regulates myoblast migration and differentiation by interacting with NUDC and modulating cell adhesion proteins, independent of proteasome activity.

This study identifies early impairments in satellite cells of a porcine DMD model using multi-omics analysis, showing intrinsic genetic defects rather than environmental factors.

This study identifies endosomal pathway dysfunction in DMD muscle cells and shows that Rab5 upregulation contributes to endosomal defects, which can be mitigated by Rab5 knock-down or dystrophin restoration.

This study uses proteomics to show sex-specific differences in mitochondrial protein response to exercise in a mouse model of FSHD, highlighting potential sex-specific biomarkers.

This study identifies fibro-adipogenic progenitors and macrophages as key players in elderly human skeletal muscle regeneration through spatial and single-cell transcriptomics, revealing their interplay via complement factor C3.

This study uses scRNA-seq to show that DMD satellite cells have molecular impairments and altered differentiation trajectories, leading to reduced regenerative capacity, with autophagy induction potentially rescuing differentiation.

The paper quantifies age-associated activity changes in DE50-MD dogs using accelerometers, finding reduced activity and increased rest time in affected dogs compared to controls.

This study shows that inhibiting the TWEAK/Fn14 signaling reduces skeletal muscle wasting and tumor growth in cancer cachexia models.

The paper examines how chronic resistance training and acute fatigue affect passive viscoelastic properties of human skeletal muscle fibers, finding greater responsiveness in males than females.

This paper introduces a method called collablot to quantify collagen VI levels and structural disorganisation in cell cultures from patients with collagen VI-related dystrophies, showing its effectiveness in detecting treatment effects and structural changes.

This paper maps dystrophin isoform expression across human brain development and adulthood, revealing novel expression patterns in neurons and synapses.

This study examines how frailty syndrome affects skeletal muscle histology in mice and shows that exercise can prevent these negative changes.

This paper introduces SMPFO, a method combining fluorescence assays and proteome profiling to study skeletal muscle, revealing reduced myofiber subtype divergence in nemaline myopathy.