Jeffrey J. Widrick

This paper presents a mouse model of ADSS1 myopathy by knocking out Adss1 and characterizes its motor deficits and histopathological features.

This study shows that increasing JAG1 expression in dystrophin-deficient mice improves muscle size, strength, and myofiber number.

This paper develops a high-resolution kinematic method to quantify impaired mobility in dystrophic zebrafish larvae, finding significant differences in swimming performance between mutants and wild-types.

This study identifies KLHL41's role in sarcomere assembly and muscle growth in zebrafish models of nemaline myopathy, revealing its importance in myofibril formation and cross-bridge regulation.

This study investigates the effects of conditional dystrophin ablation in skeletal muscle and brain, revealing functional deficits and pathway dysregulation in both tissues.

This study shows that DOCK3 is essential for skeletal muscle regeneration and glucose metabolism, with its loss causing metabolic dysfunction and impaired muscle repair.

This study identifies KLHL40 as a negative regulator of ER-Golgi trafficking through ubiquitylation, revealing its role in skeletal muscle development and disease.

The paper shows miR-486 is reduced in DMD muscles and its loss causes muscle and cardiac defects, identifying it as a driver of disease and a potential biomarker.

This study identifies DDX27 as a regulator of skeletal muscle growth and regeneration by modulating translational processes and ribosome biogenesis in zebrafish.