Regulation of Appetite and Obesity

This study shows that a hypercaloric diet causes temporary molecular changes in astrocytes specifically in the arcuate nucleus of the hypothalamus.

This study confirms that Krtcap3 affects adiposity and demonstrates sex-specific effects on body weight, food intake, and insulin sensitivity in rats.

This study shows that blocking ghrelin receptor signaling in fasted male rats restores conditioned passive avoidance behavior and increases neural circuit activation in specific brain regions.

This study identifies a hypothalamic-brainstem pathway involving PPG neurons in stress-induced anxiety-like behaviours and hypophagia, with sex-dependent effects.

The paper uses single-cell RNA sequencing to study the developmental origins of POMC neurons and identifies distinct transcriptional programs leading to different neuropeptidergic phenotypes.

This study shows that impaired metabolic-sensing in AgRP neurons reduces dopamine release in the dorsal striatum and suppresses reward-seeking behavior, especially under hunger.

The paper identifies differentially expressed mRNAs and microRNAs in human brain tissues associated with obesity and BMI using RNA sequencing from multiple cohorts.

This study examines how body weight and energy homeostasis affect effective connectivity between hypothalamic regions using resting-state fMRI in humans.

This study shows DVC astrocytes do not respond to systemic glucoprivation and their activation does not restore blood glucose in mice.

The paper identifies a conserved population of GABAergic Glp1r-expressing LepRb neurons that mediate leptin's suppression of food intake and prevention of obesity.

The paper maps PVNMC4R+ neural circuits and shows their role in thermogenesis, cardiovascular control, and behavioral changes beyond feeding.

This study investigates how ghrelin signaling in the ventral hippocampus influences feeding behavior by modulating specific neuronal circuits in mice.

This study shows that deleting Stim1 in Kiss1 neurons increases their excitability and protects against diet-induced obesity.

The paper identifies functional heterogeneity in POMC neurons and shows that mTORC1 signaling regulates their distinct roles in feeding behavior.

The paper investigates how short-term high-fat diet affects circadian rhythms and neuronal activity in the rat nucleus of the solitary tract, impacting satiety control.

This study shows that olfactory cues of palatable food increase meal frequency and chow overconsumption in sated rats, involving the orexigenic ghrelin system in the hypothalamic arcuate nucleus.

This study overexpresses NPGL in mice to induce obesity, showing increased food intake, body mass, and lipid metabolism gene expression.

This study shows that VTA MC3R neurons regulate feeding with sex- and activity-dependent effects, where activation reduces feeding in females and inhibition reduces feeding in males.

This study identifies Neurotensin-expressing neurons in the mouse IPAC that regulate energy balance by modulating feeding behavior and physical activity.

The paper uses neural network modeling to show increased top-down excitation from the insula to the hypothalamus and reduced prefrontal cortex excitation in obesity, regardless of hunger state.

This study shows that hypothalamic perineuronal nets (PNNs) are regulated by sex, gonadal hormones, and dietary interventions in a region-specific manner.

The paper shows that estrogen enhances activity in melanocortin neurons, reducing sedentary behavior and linking estrogen signaling to metabolic regulation.

This study shows that high-fat diet causes AgRP neurons to lose GABAergic inhibition, leading to persistent hyperexcitability despite increased inhibitory input.

The paper identifies the prevalence and phenotypic impact of loss of function mutations in the MC4R gene in a UK birth cohort, finding a 0.30% carrier rate with significant effects on body weight and BMI.

The paper identifies conserved VMH neuron populations across species using TRAP-seq and snRNA-seq data, defining six major neuron classes with distinct anatomical and genetic features.

The paper uses single-nucleus RNA sequencing to analyze the mouse hindbrain's AP and NTS in fed and fasted states, identifying transcriptional changes and receptor expression patterns relevant to obesity therapies.

The paper shows that BDNF neurons in the dorsomedial hypothalamus integrate thermal signals to regulate energy expenditure and thermogenesis during cold defense.

The paper identifies a circuit between the insular cortex and central amygdala that promotes overconsumption by suppressing satiety signals through nitric oxide synthase-1 neurons.

This study shows that protein restriction increases VTA neural activity during protein consumption compared to carbohydrate in rats, highlighting the role of VTA circuits in protein appetite.

The paper shows that central and peripheral GLP-1 systems independently suppress eating, and PPGNTS neuron activation addsitively enhances this effect with GLP-1 agonists.