Bacterial biofilms and quorum sensing

This study identifies PhoPQ as a regulator of quorum sensing in small colony variants of Pseudomonas aeruginosa, showing its role in virulence factor production and subpopulation adaptation.

This study identifies potential inhibitors of Pseudomonas aeruginosa biofilm-EPS, persistence, and quinolone signalling using mangrove-derived phytochemicals through in-silico methods.

The paper shows how spatial organization and mechanical pushing enable susceptible bacteria to survive antibiotic stress through collective behavior.

This study determines the cryo-EM structures of CqsS and its interaction with CqsA and CAI-1, revealing the molecular mechanism of quorum-sensing signal transduction in Vibrio harveyi.

This study shows that 3-oxo-C12HSL from Pseudomonas aeruginosa induces apoptosis in HNSCC cells via T2R14 and mitochondrial calcium uniporter.

This paper investigates how structural features of LuxR-type receptors determine their ligand-response mechanisms, showing that the ligand-binding domain primarily dictates associative vs. dissociative activity.

The paper investigates how microbial interactions are shaped by environmental resources versus species-produced metabolites using a controlled assay with nasal bacterial strains.

This study shows that cell motility in microbial communities disrupts clonal clustering, increases spatial intermixing, and enhances metabolic interactions and community productivity.

The paper shows that during biofilm dispersal, a subpopulation of cells forms a resilient post-dispersal biofilm community that can re-populate the niche and resist antibiotics and bacteriophages.

This study shows that Enterococcus faecalis increases antibiotic resistance in Pseudomonas aeruginosa within iron-limited biofilms by inducing specific transcriptional changes.

This study shows that polymicrobial communities can alter antibiotic susceptibilities through synergism and antagonism, and demonstrates that combining gentamicin and cephalexin can effectively clear such infections.

This study shows that charged agar surfaces alter E. coli biofilm properties by influencing curli amyloid quantity and quality, affecting structure and stability.

This study shows Pseudomonas aeruginosa uses energy-dependent T4P idling to balance dispersal and infection in fluctuating nutrient environments.

This study designs and evaluates new inhibitors of PqsE, an enzyme in P. aeruginosa, to disrupt its interaction with RhlR and reduce virulence.

This study shows Pseudomonas aeruginosa uses different antagonistic strategies to outcompete Burkholderia cenocepacia and Staphylococcus aureus, depending on the competitor's growth rate.

This study identifies dispersal-specific transcriptional biomarkers in Pseudomonas aeruginosa biofilms by analyzing gene expression across attachment, maturation, and dispersal stages.

The paper identifies a porphyrin-binding protein from Flavobacterium quisquiliarum that disrupts Pseudomonas aeruginosa biofilms by sequestering porphyrins and affecting iron homeostasis.

This study evolves K. pneumoniae biofilms in vitro to identify adaptive changes linked to infection, finding convergent mutations affecting capsule, fimbriae, and c-di-GMP pathways.

This study evaluates a triple-modality therapy combining bacteriophages, antibiotics, and antimicrobial peptides to eradicate multidrug-resistant S. marcescens biofilms in vitro.

This study shows that calprotectin affects Pseudomonas aeruginosa and Staphylococcus aureus cocultures through metal-independent mechanisms involving alkylquinolone production and quorum sensing.

This study identifies key residues in RhlR that determine ligand specificity and shows how ligand-driven gene regulation affects phenazine gene expression in Pseudomonas aeruginosa.

The paper develops liposomal nano-sensors to measure osmotic pressure gradients in E. coli biofilms, revealing radial increases linked to biofilm structure, metabolism, and expansion.

The paper shows how matrix chemistry in bacterial biofilms affects metabolism and fitness by modulating pyocyanin retention and electron transfer efficiency.

This study shows that Pseudomonas aeruginosa uses motility to enhance phagocytosis by macrophages, while reduced motility in chronic infections helps evade engulfment, and T3SS activity enables acute immune evasion.

This study shows that type 1 fimbriae and adhesins promote microcolony formation, shielding bacteria from short-range contact-dependent weapons and maintaining phenotypic heterogeneity.

The paper develops FRET-based c-di-GMP biosensors and applies them with FRET-To-Sort to map regulatory networks controlling c-di-GMP levels in E. coli.

This paper identifies AmrZ as a global regulator in Azotobacter vinelandii that links alginate production to c-di-GMP homeostasis by directly activating algD and specific DGCs, while reducing motility.

This paper shows that NbdA, a phosphodiesterase in Pseudomonas aeruginosa, modulates c-di-GMP levels and affects type IV pilus function, influencing surface behavior and phage resistance.