Neurogenesis and neuroplasticity mechanisms

The paper compares gene expression in immature neurons across species to identify human-specific features and shared biological processes.

The paper shows microglia regulate GABAergic neurogenesis in the prenatal human brain via IGF1, using single-cell transcriptomics and organoid models.

The paper shows that Wntless restricts Notch signaling to balance neuron and gliocyte generation in zebrafish dorsal diencephalon.

The paper investigates the geometric principles governing the morphology of oligodendrocyte precursor cells (OPCs) in the mouse corpus callosum using imaging and morphometric analysis.

The paper shows that disrupting epigenetic barriers in olfactory placode-derived cells can induce stem cell-like characteristics through genetic perturbations.

This study identifies CCB79 as a primate-specific protein essential for maintaining neural progenitor diversity in developing brains by regulating ciliogenesis.

The paper investigates the spatial and temporal origins of interneuron subtypes in the caudal ganglionic eminence (CGE) and shows that specific subtypes arise from distinct CGE subdomains with stable spatial biases over time.

This study identifies Sox5 as a regulator of quiescence in neural stem cells during postnatal development, showing its role in balancing primed and deep quiescence to maintain adult neurogenesis.

This study shows that CIP4 and FBP17 regulate radial neuron migration and neurite outgrowth in the developing cortex by modulating neuronal morphology.

This study uses mathematical models to analyze regulatory feedback mechanisms in adult neurogenesis, finding that neural stem cells predominantly regulate lineage dynamics.

This study investigates the role of oligodendroglial ADAM10 in myelin development and maintenance, finding that its deficiency causes delayed oligodendrocyte maturation and myelin defects with sexual dimorphism in adult mice.

The paper shows safety learning in the infralimbic cortex recruits oligodendrocyte progenitor cells to PV interneurons, promoting PNN degradation and cognitive flexibility.

This study shows that DNMT1 regulates the migration of somatostatin-expressing interneurons, affecting cortical layer structure and function in mice.

This study develops a method to isolate oligodendrocyte-lineage cells from postmortem brain tissue and finds age-related gene expression changes and a correlation between oligodendrocyte density and myelin area in the basolateral amygdala.

This study identifies TMEM63A as a critical regulator of myelination in the CNS, showing its role in oligodendrocyte function and linking its dysfunction to hypomyelinating leukodystrophies.

The paper identifies Thbs4-positive astrocytes from the SVZ that modulate the extracellular matrix at the glial scar after brain ischemia by synthesizing and degrading hyaluronan.

This study identifies a global temporal chromatin programme in vertebrate neural progenitors that integrates with spatial patterning to regulate cell fate and identity.

This study identifies a molecular switch driven by neuronal activity and PGC-1 that promotes the maturation of parvalbumin interneurons during postnatal development.

The temporal analysis of gene regulatory networks in human neural stem cells reveals multiple early critical phases associated with cortical disorders and neuropsychiatric traits.

The paper investigates the role of Yap and Taz in OEC and Schwann cell development using single-cell RNA sequencing and conditional ablation in mice, finding differential impacts without affecting GnRH-1 migration.

This study shows that methyl gallate improves post-stroke depression and cognitive impairments by enhancing hippocampal neurogenesis through PI3K/GSK3 and AMPK signaling.

This study investigates GPR17's role in oligodendrocyte precursor cell maturation and myelin regeneration, finding limited impact on myelin repair after injury.

The paper identifies two lineage-committed progenitors in the developing brain that generate forebrain/midbrain and hindbrain regions, and demonstrates their distinct chromatin landscapes and differentiation potential.

This paper develops a method to generate MGE organoids from hPSCs that robustly produce PV-expressing interneurons and reveals migration deficits in SLC6A1-deficient interneurons.

The paper shows that 24S,25-epoxysterol, an oxysterol linked to neurodevelopmental disorders, promotes neurogenesis and disrupts GABAergic neuronal subtype composition through the liver X receptor pathway.

This study shows that NKCC1 regulates hippocampal neural stem cell self-renewal via Sox11, with reduced NKCC1 in aging promoting symmetric division and decreased neurogenesis.

This study examines the functional maturation and experience-dependent plasticity of adult-born dopaminergic neurons in the olfactory bulb of mice, finding they rapidly acquire mature properties and show limited plasticity.

This study shows that α7 nicotinic acetylcholine receptors influence radial glia fate in human cortical development, with nicotine exposure altering neuronal differentiation and RG proliferation.

The paper shows Notch signaling epigenetically primes neural progenitors to enhance Sonic Hedgehog signaling and promote oligodendrocyte differentiation in the developing mouse forebrain.

This study shows that hypermyelination in FusOLcKO mice enhances hippocampal neuronal activity detection but disrupts cortical network communication.