Steven M. Wellman

This study shows that long-term locus coeruleus stimulation worsens memory, synaptic plasticity, and Tau pathology in PS19 mice.

This study shows that immunoproteasome deficiency in mice worsens tau and amyloid pathology by impairing microglial clearance.

This study shows aging reduces functional connectivity in mouse V1 and CA1 regions, affecting synchrony in specific frequency bands without impairing single-neuron activity.

This study shows that hypermyelination in FusOLcKO mice enhances hippocampal neuronal activity detection but disrupts cortical network communication.

This study maps brain-wide, cell-type-specific gene expression changes in mice following LC-NE system activation or inhibition using single-nucleus RNA sequencing.

This study observes dynamic structural and functional changes in brain pericytes and immune cells around chronically implanted microelectrodes over four weeks.

This study shows that LIPUS reduces microglial activation and improves tissue-microelectrode integration after intracortical implantation.

This study evaluates how electrode sharpness and insertion speed affect tissue damage when implanting high-density neural arrays in mice and rats, finding that electro-sharpened arrays and faster insertion reduce cellular damage and BBB compromise.

The paper investigates the accumulation of age- and disease-associated factors around chronically implanted microelectrodes in a mouse model of Alzheimer's disease using two-photon microscopy.