Takashi D.Y. Kozai

This study shows astrocytes actively shape neural activity during intracortical microstimulation by modulating calcium signaling, influencing neuronal responses in a pattern-dependent manner.

This study investigates how PV and SOM interneurons respond to different microstimulation patterns and how their activation dynamics influence cortical network activity and adaptation.

This study examines chronic effects of intracortical microstimulation on visual cortex function in awake mice, finding progressive neuronal and vascular responses with neurovascular uncoupling and frequency-dependent after discharges.

This study shows that 10-Hz intracortical microstimulation directs microglial surveillance toward activated neurons, revealing their role in modulating cortical circuits during early post-implantation.

The paper shows that enhancing oligodendrocyte function in a mouse model of Alzheimer's Disease reduces neuronal damage and slows disease progression.

The paper uses a finite element model to predict tissue strain from micromotion in Utah arrays and correlates these strains with electrode performance in humans and non-human primates.

This study shows aging reduces functional connectivity in mouse V1 and CA1 regions, affecting synchrony in specific frequency bands without impairing single-neuron activity.

This study shows that hypermyelination in FusOLcKO mice enhances hippocampal neuronal activity detection but disrupts cortical network communication.

This study examines how sustained and bursting electrical microstimulation affects excitatory and inhibitory neuron activation in the visual cortex of transgenic mice over 30 seconds.

This study observes dynamic structural and functional changes in brain pericytes and immune cells around chronically implanted microelectrodes over four weeks.

This study explores photoelectric stimulation using ultrasmall carbon electrodes to modulate neural tissue, showing improved voltage generation and potential for precise chemical delivery.

This study shows that LIPUS reduces microglial activation and improves tissue-microelectrode integration after intracortical implantation.

The paper shows that optogenetic stimulation of parvalbumin interneurons in awake mice induces depth-dependent cerebrovascular responses, including delayed slow increases in cerebral blood flow.

This study examines how chronic microelectrode implantation affects functional connectivity in different cortical layers and the hippocampus over 16 weeks, finding layer-specific impairments and altered interlaminar communication.

This study investigates how different microstimulation frequencies affect neural and hemodynamic responses in the mouse visual cortex, finding that lower frequencies enhance activation while higher frequencies induce depression.

This study evaluates how electrode sharpness and insertion speed affect tissue damage when implanting high-density neural arrays in mice and rats, finding that electro-sharpened arrays and faster insertion reduce cellular damage and BBB compromise.

The paper shows that Clemastine treatment improves microelectrode recording performance and neuronal health by enhancing oligodendrocyte activity during chronic implantation.

The paper investigates the accumulation of age- and disease-associated factors around chronically implanted microelectrodes in a mouse model of Alzheimer's disease using two-photon microscopy.

This study evaluates how biomimetic microstimulation affects neural activity in sensory cortices, finding that amplitude modulation reduces stimulation-induced depression and improves onset/offset detection.

This study shows that different ICMS pulse waveforms and frequencies activate distinct patterns of cortical neurons and neuropil in mice, with frequency-dependent effects on population activity.

The paper introduces the Argo System, a high-density neural recording system with 65,536 channels, validated in rats and sheep for cortical recordings.

This study investigates how frequency-dependent electrical stimulation affects calcium activity in cortical neurons, revealing spatiotemporal response patterns that depend on charge density and frequency.