Neurogenesis and neuroplasticity mechanisms

The paper shows that cortical layering in tetrapods follows conserved developmental principles, with mammals displaying an inverted layer order.

This study identifies YAP1's role in regulating oligodendrocyte-astrocyte fate switch and ependymal gene expression in adult spinal cord stem cells through in vitro experiments and multi-omic profiling.

This study identifies AGO1's role in neural progenitor cells in brain development and sociability through the LIN28A-REELIN axis, showing its impact on ASD-related phenotypes.

This study shows that PSA-MAP scaffolds enhance early neural regeneration after ischemic stroke by increasing progenitor cells and axonal content without significant changes in astrocytic or vascular coverage.

This study shows that hypoxic preconditioning of human iPSC-derived neural progenitor cells improves their survival and function after transplantation in a stroke mouse model.

This study shows that TS21 accelerates radial glia lineage progression, leading to premature production of inhibitory neurons and oligodendrocytes in Down syndrome.

The paper investigates miR155's role in hippocampal GABAergic neurogenesis in Alzheimer's disease, finding it regulates NSC dynamics and interneuron development with opposing effects compared to microglial miR155.

The paper investigates how altering cell size asymmetry in Drosophila neural stem cells affects their proliferation and lineage potential, finding increased stem cell pools but reduced lineage size and differentiation.

The paper identifies H3K27me3-mediated repression and -ketoglutarate as key regulators of species-specific neurogenesis timescales across mammals.

This study shows that PSD-95 in oligodendrocytes is essential for activity-dependent myelin sheath growth through axon-oligodendrocyte connectivity in zebrafish.

This study identifies cortical tension as a mechanical barrier that prevents premature neuronal differentiation during neurogenesis, showing that reducing it accelerates neuronal lineage commitment and differentiation.

This study characterizes adult hippocampal neurogenesis in AppKI mice, showing age-related deficits and environmental enrichment's protective effect.

The paper investigates how environmental factors influence neocortical neuron fate and diversity through in vivo and in vitro experiments, showing population-specific responses and the importance of extracellular context.

This study shows that transplanting iPSC-derived neural progenitor cells improves long-term recovery after stroke in mice by promoting tissue repair and reducing neurological deficits.

This study investigates how erythropoietin (EPO) and its receptor (EPOR) regulate oligodendrocyte lineage dynamics in the adult mouse hippocampus, showing EPO promotes differentiation and maturation, and suggests potential therapeutic applications for remyelination.

The paper investigates the relationship between neurogenic timing and cortico-cortical projection identity in mouse visual cortex layer 2/3, finding distinct birthdate patterns for lateral and medial projection subtypes.

This study inhibits QPRT in human stem cell-derived cerebral organoids, revealing altered cell type distribution and metabolic stress linked to neurodevelopmental disorders.

This study introduces a viral construct that dynamically regulates NeuroD1 expression during astrocyte-to-neuron reprogramming, reducing its level in reprogrammed neurons to enhance GABAergic differentiation.

This study develops a method to generate neocortical organoids with distinct anterior-posterior molecular signatures and uses them to model Fragile X Syndrome pathology.

This study shows adducins regulate proliferation and fate of neural progenitors in mouse, ferret, and human neocortex, affecting neurogenesis.

This study shows maternal SARS-CoV-2 vaccination increases hippocampal neurogenesis and working memory in offspring mice via IFN-gamma responsive microglia.

This study investigates functional neuronal regeneration after traumatic brain injury in killifish, showing that new neurons integrate into circuits and enable behavioral recovery over 50 days.

The paper shows that combining progenitor expansion with adhesion-controlled neuronal migration enhances cortex folding in mice, leading to sulci and gyri formation.

The paper identifies molecular clusters of quiescent neural stem cells in zebrafish and shows how Notch signaling inhibition leads to distinct activation behaviors.

This study shows that species-specific fatty acid oxidation rates influence temporal patterning of corticogenesis through protein acetylation dynamics in human and mouse cortical progenitors.

The paper uses stereo-tracking to study Purkinje cell development and identifies a new subcellular structure called axon bubbles.

The paper identifies Foxp genes as regulators of Purkinje cell diversity in cerebellar development and evolution, showing their role in subtype specification and species-specific cerebellar organization.

This study shows transplanted human cortical neurons can integrate into and repair damaged motor circuits in ischemic mice by following transcriptional codes for axon guidance and synapse formation.

This study shows that NDE1 loss disrupts neural progenitor identity and forebrain patterning, leading to microcephaly through altered ERK signaling and regional identity shifts.

This study shows that reactive oxygen species (ROS) increase in the neonatal cerebellum after injury, and reducing ROS impairs regenerative processes.