Neurogenesis and neuroplasticity mechanisms

The paper uses in vivo timelapse imaging to study Golgi satellite movement in neural progenitor cells of Xenopus laevis tadpoles, revealing dynamic distribution of these organelles.

This study shows that loss of Ezh2 in the medial ganglionic eminence (MGE) leads to changes in interneuron fate, morphology, and gene expression.

This study evaluates how host brain age and region affect the survival, migration, and differentiation of transplanted MGE progenitors, finding that early postnatal transplantation yields better outcomes.

The paper identifies a subpopulation of embryonic neural stem cells in zebrafish with transcriptional features of adult quiescent NSCs, suggesting a developmental transition to quiescence.

This study shows that loss of NMDA receptor function in zebrafish leads to reduced KCC2 expression and increased neurons in the forebrain during post-embryonic neurogenesis.

The study identifies histone modifications H4K8ac and H4K20me3 that regulate transcriptional differences between adult and neonatal oligodendrocyte progenitors.

This study shows that OTX2 in parvalbumin interneurons of the piriform cortex affects their maturation and olfactory behavior in mice.

The paper uses in vivo two-photon imaging in transgenic songbirds to show that adult neuron migration follows a superdiffusive model, which can explain the dispersion of new neurons in the HVC.

This study identifies a retroviral origin of vertebrate myelin by showing that RNLTR12-int retrotransposon regulates myelination through SOX10 interaction in multiple vertebrates.

Chromatin regulators including EZH2, EHMT1/2, and DOT1L establish an epigenetic barrier in human neural progenitors that poises maturation genes and sets the protracted pace of cortical neuron maturation.

This study investigates ARX's role in cortical interneuron development and migration, identifying its regulatory impact on proliferation, fate specification, and cell-cell communication.

The paper shows that deletion of the Pcdhγc4 isoform increases cortical interneuron cell death, while viral expression rescues it, highlighting its critical role in regulating survival during programmed cell death.

This paper demonstrates that transient suppression of PTBP1 in aged glial cells can re-activate neurogenesis in murine and human brains, generating new neurons through canonical pathways.

This study isolates and characterizes neural stem cells from activated neurogenic niches after traumatic brain injury in rats, finding distinct in vitro behaviors compared to uninjured controls.

This study investigates how different types of spinal cord injury affect the proliferative and neurogenic potential of neural stem cells derived from the central canal in rats.

The paper identifies hippocampal reactive neural stem cells (react-NSCs) as phagocytic and immunologically active cells in two pathological models, MTLE and TBI.

This study shows Beclin1 is required for mitosis and DNA maintenance in adult neural stem cells, leading to reduced neurogenesis.

This study measures lysosomal protein degradation in neural stem cells of postnatal mouse brain and finds age and disease-related fluctuations in lysosomal activity.

This study uses single-cell RNA sequencing to show that Treponema pallidum infection impairs neurodevelopment in iPSC-derived brain organoids by reducing subNPC1B cells and hindbrain neurons.

The paper identifies hindbrain boundaries as niches containing neural progenitor/stem cells regulated by chondroitin sulphate proteoglycan through transcriptomic analysis.

This study shows that chemogenetic activation of adult hippocampal progenitors increases neurogenesis and affects anxiety-like behavior and fear extinction learning in mice.

This study uses a genetic mouse model to show that choroid plexus ablation reduces subventricular zone neuroblasts and impairs post-stroke neurogenesis.

The paper shows that lesion environments, not pre-graft states, affect the survival and repair potential of neural progenitor and immature astrocyte grafts in stroke models.

This study shows that heterotopic neurons in EmlJ knockout mice retain functional properties similar to neocortical neurons despite their abnormal location.

This study shows that Arl2 regulates mouse cortical development by promoting microtubule growth through its interaction with Cdk5rap2.

This study analyzes single-cell transcriptomes of the mouse hippocampus after voluntary exercise, identifying molecular changes related to neurogenesis and signaling pathways.

This study shows PANX1 is dynamically expressed during human brain development and its loss reduces neuroepithelial expansion by disrupting adhesion, signaling, and gene regulation.

The paper identifies BRCA1 and ELK-1 as regulators of visual experience-dependent neural progenitor cell fate in Xenopus laevis optic tectum using transcriptomic and in vivo imaging analyses.

The paper identifies the lncRNA Lockd as regulating cortical NSPC cell cycle progression by counteracting cis and trans effects on Cdkn1b and Ccnd1.