Neurogenesis and neuroplasticity mechanisms

This study shows that calcium signaling in oligodendrocytes is critical for shaping myelin sheath morphology during myelination in the developing mouse CNS.

This study investigates the role of angpt1 in zebrafish brain development, showing its importance in vascular and neuronal development through interactions with itgb1b.

The paper investigates PRDM16's role in human brain development by analyzing a patient mutation and cortical organoids, revealing its collaboration with LHX2 in gene regulation.

This paper introduces a device to generate morphogen gradients for creating patterned brain organoids, revealing distinct cell types and long-term stability.

The paper identifies COX2-derived prostaglandin D2 as a promoter of spinal cord neurogenesis through in vivo drug screening and single-cell RNAseq analysis in zebrafish.

This study investigates the expression pattern of the transcription factor Isl1 in dopaminergic neurons of the developing mouse forebrain, identifying its role as a molecular marker.

The paper shows that STAT3, downstream of mTORC1, regulates astroglia generation in human brain organoids, but mTORC1 is not required for cytokine-induced STAT3 activation.

This study shows that an anti-obesity neuropeptide analogue promotes adult neurogenesis and rescues neuronal survival in diet-induced obesity.

This study shows that adult hippocampal neural stem cells (aNSCs) form in the early postnatal dentate gyrus and require cyclin D2 for their development.

This study identifies multipotent progenitors in the superior colliculus that generate all excitatory and inhibitory neuron types without extrinsic input.

The paper traces Axin2-positive cell lineage in adult hippocampal neurons, finding that Axin2 is expressed at multiple stages of differentiation and that integration of adult-born neurons can take longer than previously thought.

The paper investigates how norepinephrine modulates Ca2+ signals and fate decisions in oligodendrocyte progenitor cells (OPCs) in the cortex through behavioral and genetic approaches.

This study shows that LSD1/KDM1A is essential for neural stem cell differentiation in mice, as its deletion causes perinatal lethality and brain defects, but motor neurons can still be generated.

This study shows that transient Yamanaka factor expression during development expands the neocortex and improves cognitive function in mice, while intermittent expression in adult neurons protects against Alzheimer's disease features.

The paper introduces a new method for efficiently culturing oligodendrocyte lineage cells, improving yield and reducing time for OPC maturation into oligodendrocytes.

The paper creates high-resolution 3D atlases of postnatal mouse brains and maps changes in GABAergic cells and microglia across development.

This study investigates the effects of the 5:2 diet on adult hippocampal neurogenesis and spatial memory in mice, finding no significant impact on neurogenesis or memory performance.

This study investigates the effects of intermittent fasting on adult neural stem cells and neurogenesis in mice, finding no significant impact on NSC activation, maintenance, or neurogenesis.

This study shows FEZ1 is essential for human brain development by regulating neuronal progenitor subpopulations and migration, with its deletion causing abnormalities in cortical layer formation.

The paper identifies a ternary extracellular matrix complex in the subplate/intermediate zone that supports radial migration of cortical neurons by promoting the multipolar-to-bipolar transition.

This study shows that Dyrk1a regulates interneuron migration via actomyosin dynamics, leading to cortical GABAergic system defects and phenotypes seen in DYRK1A-haploinsufficiency syndrome.

The paper shows Neurog1 and Olig2 integrate patterning and neurogenesis signals to specify A11-type dopaminergic neurons in zebrafish.

The paper uses somatic mutations to analyze lineage divergence in human cortical regions, finding late divergence of neuronal cell types and regional inhomogeneities in progenitor proliferation.

This study reprograms early cortical astroglia into neurons with parvalbumin-positive interneuron features using a modified Ascl1 protein.

This study identifies two transcription factors that regulate neocortical size by controlling progenitor cell behavior and gene expression, with implications for microcephaly.

The paper identifies heterogeneous dividing progenitors in hindbrain rhombomere centers that rely on Notch3-signaling and exhibit distinct proliferative and neurogenic properties.

This study shows Kif23 is essential for proper cytokinesis and neural stem/progenitor cell maintenance in developing mouse and human neocortex, with its disruption leading to microcephaly-like phenotypes.

The paper shows asymmetric inheritance of centrosomes in human neural progenitor cells, maintaining self-renewal and proper neurogenesis.

This study maps the spatial-temporal development of glutamatergic neurons in embryonic cerebellar nuclei, revealing significant cellular heterogeneity and distinct subpopulations.

The paper investigates the role of Slitrk and LAR-RPTP proteins in neuronal migration during mouse cortex development, showing they influence migration independently of synaptic organizer activity.