Genetics, Aging, and Longevity in Model Organisms

This study shows that a glucose-rich diet in C. elegans causes neuron morphology issues and egg-laying defects, which are linked to serotonin signaling and the DAF16/FOXO pathway.

This study shows that disrupting a regulatory element in the CEBPA gene of African turquoise killifish increases lifespan and healthspan by enhancing full-length C/EBP isoform activity.

This study shows that DREAM complex activity influences somatic mutation burden, lifespan, and age-related disease, with reduced activity linked to longer lifespan and lower disease risk.

The paper shows that adjusting extracellular pH to prevent acidification extends yeast lifespan by enhancing the heat shock response and promoting polyQ aggregation.

This study shows that deleting SUL1 in yeast extends replicative lifespan through reduced PKA signaling, not by decreasing sulfate uptake.

The paper shows that differences in stress resistance and gut microbiome composition between Drosophila reference lines affect disease modeling outcomes in neurodegenerative conditions.

This study identifies H3K27ac as a key transcriptional switch that promotes longevity by enhancing lipid catabolism and antioxidant defenses under hormetic nutrient stress in C. elegans.

This study identifies InsP3R signaling as a mediator of mitochondrial stress-induced longevity in C. elegans through actomyosin-dependent mitochondrial dynamics.

This paper evaluates rodent frailty indexes and their implementation in aging studies, highlighting inconsistencies in frailty parameters and recommending standardized protocols.

This paper develops a multi-omic model to predict phenotypic age in mice, showing it can predict remaining lifespan even among same-aged mice.

The paper introduces a minimal model of aging that predicts two regimes and guides intervention strategies for extending healthspan and lifespan.

This study shows that Reserpine extends lifespan in Drosophila but reduces heat-stress resilience, revealing a trade-off between longevity and stress response.

This study uses single-nucleus genomics and spatial transcriptomics to show that caloric restriction modulates aging-related changes in mouse brains, reducing inflammation and stress pathways while restoring circadian and cognitive genes.

This study identifies molecular signatures of aging in the mouse brain through proteo-transcriptomic analysis, revealing changes in protein aggregation, mRNA relocalization, and translation efficiency linked to neurodegeneration.

The paper develops and integrates multi-organ proteome-based biological age gaps (ProtBAGs) with phenotype-based age gaps to explore their genetic and clinical implications in aging and disease.

The paper compares aging markers between surface and cavefish populations of Astyanax mexicanus, finding that cavefish show less pronounced aging signatures and suggest metabolic shifts, particularly mitochondrial function, contribute to their extended longevity.

The paper shows that gut microbiota in Drosophila affect ageing through Acetobacter, Tachykinin, and TkR99D, extending lifespan without reducing fecundity.

This study shows that autophagy gene knockdown in C. elegans affects lifespan in a highly condition-dependent manner, with variable outcomes based on genetic background, temperature, and experimental conditions.

This study identifies DIMT-1 as a regulator of C. elegans lifespan and stress resistance through its role in rRNA methylation and germline function.

This study shows that dietary BCAA restriction mitigates metabolic issues and cellular senescence in mice, with tissue-specific effects observed.

The paper introduces SkeletAge, a bulk RNA-seq-based aging clock that identifies 26 novel genes in skeletal muscle aging and links them to aging phenotypes and drug targets.

This study expresses a naked mole-rat HA synthase 2 transgene in mice, finding improved healthspan but no reduction in age-related hearing loss.

This paper identifies NHR-49 as a regulator of oocyte activation and ovulation in C. elegans, linking fertility, resource allocation, and longevity through its role in controlling GSA-1 expression.

This study examines age-related increases in infection susceptibility in Drosophila melanogaster, finding that susceptibility rises early in life and is linked to reduced tolerance rather than resistance, with distinct effects on male lifespan.

This study shows dietary zinc and protein-to-carbohydrate ratio interact to regulate reproduction and lifespan in Drosophila, with Zn having effects comparable to macronutrient adjustments.

The paper identifies compounds that extend mouse lifespan and healthspan using a biomarker-driven platform integrating gene expression, chemical screening, and lifespan studies.

The paper identifies a UPRmt modulator, fipp-1/FIP1L1, that extends lifespan in C. elegans and is associated with metabolic homeostasis in humans.

This study shows that daf-16/FOXO activity before dauer diapause enables dauer exit and post-dauer development by promoting cholesterol retention and DAF-12 ligand synthesis.

This study shows that dietary restriction extends lifespan in C. elegans by suppressing fertility, not through adaptive hypotheses, and suggests mutation accumulation drives this evolutionary effect.