Genetics, Aging, and Longevity in Model Organisms

This paper identifies estrogen-mediated suppression of IL-11 as a hormonal mechanism contributing to female longevity advantage by reducing inflammaging and multi-organ fibrosis.

This study identifies fard-1 and dhs-25 as regulators of ferroptosis-driven aging in C. elegans by linking redox imbalance to oxidative stress and lifespan reduction.

Engineered spermidine-secreting Saccharomyces boulardii improves olfactory memory in Drosophila without affecting locomotion.

This study shows that selecting late progeny in C. elegans over multiple generations reduces stress resistance and lifespan but preserves reproductive output.

This study shows that touch perception interacts with dietary restriction to modulate lifespan in C. elegans through bioamine and neuroendocrine signaling.

This study examines how genotype and sex influence paraquat-induced oxidative stress effects on functional aging and lifespan in Drosophila melanogaster.

The paper identifies post-translationally modified amino acids (ptmAAs) as age-related plasma metabolites in dogs, linking them to kidney function and dietary factors.

This study examines the relationship between frailty index scores and cognitive performance in mice across different ages, finding that frailty index correlates with specific behavioral and cognitive tasks.

The paper compares the effects of three different germline mutations on longevity and fat metabolism in C. elegans, finding distinct physiological outcomes.

The paper investigates gene expression changes during and after dauer diapause in C. elegans, revealing age deceleration and reversal patterns.

This study identifies strain-specific longevity benefits of human gut Bifidobacteria in C. elegans, showing they rely on distinct cytoprotective pathways but share dependence on host lipid regulation.

The paper examines an energetic trade-off model linking inflammaging and immunosenescence using data from the US Health and Retirement Study and UK Biobank, finding evidence of TNFR1 and GDF15 mediating age-related immune declines and health risks.

This study identifies early brain-wide reductions in cell size and volume during adulthood in Drosophila melanogaster, linked to aging and modifiable by Myc overexpression.

The paper examines age-related morphological changes in the C. elegans germline stem cell niche and identifies non-autonomous regulation by insulin/IGF-like signaling.

The paper identifies six genes with causal roles in aging by analyzing gene expression across species and testing their effects on lifespan in C. elegans.

The paper uses iPSC-derived neurons from centenarians to identify resilience signatures associated with longevity, showing enhanced stress response and specific transcriptional programs.

This study identifies bacterial exposure as a key driver of immune ageing and shows residual bacterial DNA in immune cells predicts immune age changes.

This study shows that a hyperactive 20S proteasome in C. elegans improves degradation of misfolded proteins, reduces oxidative damage, and extends lifespan without relying on known proteostasis pathways.

The paper introduces a high-throughput microfluidic assay to study gametogenic rejuvenation in yeast and identifies Atg39 and Atg40 as molecular determinants of lifespan resetting.

This study analyzes transcriptomes across 35 human tissues to show sex-dimorphic aging patterns and their links to Alzheimer's disease and hormone levels.

The paper identifies a protein condensation network in yeast that integrates internal and external signals to regulate cell fate decisions during senescence and pheromone response.

The paper shows that bacterial-derived RNA extends healthspan in C. elegans by reducing protein aggregation through inter-tissue communication and systemic RNAi.

This study shows that rapalink-1, a mTOR inhibitor, extends lifespan in fission yeast by modulating an agmatinergic metabolic feedback circuit that regulates mTOR activity.

The paper introduces PathStAR, a framework to quantify structural aging from histopathology images, revealing tissue-specific aging trajectories and coordinated deterioration across organs.

This study shows that glucagon receptor signaling is essential for the healthspan benefits of caloric restriction in aging male mice, as its absence reduces lifespan and impairs metabolic improvements.

This study shows lactate extends C. elegans lifespan via redox-driven lipid remodeling and involves SIRT1 and RICTOR.

A marsh samphire extract extends female Drosophila lifespan and reduces body fat, with effects dependent on Tor signaling and counteracting intestinal barrier loss.

This study investigates how genetic variation affects phenotypic responses to diet and aging in Drosophila melanogaster, finding significant genotype-by-diet and genotype-by-age interactions.

This study presents a longitudinal assessment of age-related changes in Brown-Norway rat physiology and histopathology at 6, 17, and 27 months of age to provide healthspan parameters for aging research.

This study identifies T13F2.2 as a critical gene in C. elegans that affects chromatin structure, autophagy, and lifespan through RNAi depletion and transcriptomic analysis.