Retinal Development and Disorders

This study shows that NMNAT1 deletion in developing murine retina causes severe photoreceptor and inner retinal neuron degeneration through multiple cell death pathways and metabolic disruptions.

This study investigates the effects of embryonic hyperglycemia on retinal cell development in zebrafish, finding reduced photoreceptor and horizontal cell numbers and increased reactive oxygen species.

The paper identifies a retinal circuit where A2 amacrine cells inhibit OFF ganglion cells in the ON layer, contradicting established connectivity and receptive field rules.

The paper shows that FGF and Wnt signaling gradients determine phase transitions in vertebrate eye cup development, specifying cell fates through their combinatorial code.

This study examines the expression patterns of Nuclear Factor I (NFI) isoforms in retinas of chick, pig, and monkey, finding that NFIA and NFIB are expressed in developing and mature retinal cells, with reduced levels in proliferating Muller glia-derived progenitor cells.

This study identifies gene regulatory networks controlling retinal development by integrating single-cell RNA and ATAC-seq data from mouse and human retinas, revealing transcription factors that regulate temporal patterning and cell fate.

This study shows that zebrafish retinal cell proliferation declines with age, contradicting the assumption of continuous neurogenesis throughout life.

This paper develops a computational model to study retinal mosaic formation, finding that cell migration yields the most regular mosaics and that SAC populations in GCL and INL may not be independent.

This paper develops mathematical models under the trophic factor hypothesis to predict cone degeneration in retinitis pigmentosa following rod loss.

This study shows that loss of rlbp1a in zebrafish causes cone dysfunction, lipid deposits, and photoreceptor degeneration, mimicking human retinal diseases caused by RLBP1 mutations.

The paper uses spectral responses of bipolar cells in zebrafish to infer integration rules in the inner retina, revealing six dominant spectral motifs and a new axis of spectral opponency.

This study examines the impact of Kv8.2 loss on rod and cone photoreceptor signaling and degeneration using a knockout mouse model.

This study identifies early mitochondrial stress and metabolic imbalances as key drivers of photoreceptor cell death in retinal degeneration using a multi-omics approach in a mouse model.

This paper describes retinal development and remodeling in the brown anole lizard, identifying key features of fovea formation and its relationship to eye shape changes.

This study investigates how inflammation affects retinal regeneration in zebrafish following acute or chronic damage, showing differential microglia responses and cytokine gene expression.

This study shows that zebrafish RPE cells stretch to match retinal curvature during optic cup formation, with proliferation and cytoskeletal interference affecting this process.

This study shows that Brn3a and Ret interact in retinal ganglion cell type specification, with Brn3a loss affecting Ret co-receptors and neurotrophin receptors.

This study shows that human retinal progenitor cells derived from primitive mesenchymal stem cells improve retinal function and structure in a mouse model of retinal degeneration.

The paper assesses the short-term effects of AAV2-hCHM gene injections on cone mosaic integrity in CHM patients using AOSLO and finds preservation of the mosaic with minor foveal thinning.

The paper analyzes RPE65 variants in 45 patients with retinal dystrophy, finding associations between variant types and age at onset.

This study identifies widespread translational regulation during mouse retinal development, revealing dynamic translational changes and novel micropeptides involved in retinal function.

This study shows that GSK3 signaling regulates the genesis of displaced ganglion cells in the retina, with loss of GSK3 leading to increased numbers of these cells and altered axon projections.

The paper identifies a shift in the active miRNA targetome in a mouse model of retinal degeneration, showing changes in miRNA binding regions and AGO2 localization.

This study shows that postnatal retinal neurogenesis in mice is modulated by visual experience during a critical period ending around postnatal day 70.

This paper demonstrates that transplanted human photoreceptors from iPSC retinal organoids extensively incorporate into a murine cone degeneration model, leading to improved maturation, polarisation, and functional integration.

The paper identifies Notch signaling components that regulate Muller glia's regenerative response to retinal injury by modulating injury-response threshold and progenitor proliferation.

The paper investigates the molecular evolution of UV-sensitive opsins in anemonefishes, identifying gene duplications and expression patterns that contribute to UV vision.

This study shows that Arap1 in retinal pigment epithelium (RPE) is essential for photoreceptor survival through its role in phagocytosis, as Arap1 deficiency leads to photoreceptor degeneration.

This study identifies CN238, a novel PKG inhibitor, as a neuroprotective agent that preserves photoreceptor and ganglion cell viability and function in retinal degeneration models.

This study shows that Lyst deficiency in mice leads to retinal detachment by causing phagosome accumulation and increased proteases in retinal pigment epithelial cells.