Mario Ledesma-Terrón

NucLogic provides a fast and robust 3D nuclear segmentation method that outperforms existing tools at low SNR and enables quantitative analysis of challenging biological imaging data.

This study shows that cell competition in the liver promotes metastatic intestinal cancer through a multistage process involving compaction, cell cycle arrest, differentiation, and reduced cellular fitness.

The paper quantifies retinal neurogenesis dynamics, showing exponential growth and neuronal yield are regulated by Hedgehog signaling balancing differentiation and cell cycle duration.

This study shows that zebrafish RPE cells stretch to match retinal curvature during optic cup formation, with proliferation and cytoskeletal interference affecting this process.

OSCAR quantifies densely packed 3D biological samples by reconstructing objects in 3D space and identifying cell fates in zebrafish retina.

This study shows FGF2 increases growth fraction, promotes symmetric divisions, and shortens the cell cycle in Radial Glial progenitors, enabling their expansion in vitro.