Forensic and Genetic Research

This study develops a data synthesis framework to accurately infer genetic ancestry from cancer-derived molecular data across genomic platforms, showing high accuracy across different sequencing depths and modalities.

This study analyzes ancient genomes from Upper Mesopotamia during the Neolithic Transition, revealing genetic diversity, immigration, and cultural practices such as head-shaping.

The paper tests three reagents for in-solution enrichment of ancient human DNA and introduces a subset of SNPs that can be co-analyzed with shotgun data.

The paper shows that admixture in modern European genomes has masked over 50 historic hard sweeps, suggesting underappreciation of historical selection in human evolution.

The paper uses genome-wide data to analyze the genetic relationships of six early Medieval Korean individuals buried together in a jar coffin, finding they form an extended family with no significant genetic change over 1,500 years.

KIN estimates relatedness from low-coverage ancient DNA by analyzing identical-by-descent segments, accurately classifying up to 3rd-degree relatives and distinguishing siblings from parent-child.

This study validates the Illumina Infinium assay using the Global Screening Array (GSA) for forensic applications according to SWGDAM guidelines, showing high SNP call rates and sample quality assessment methods.

sstar is a Python package that improves detection of archaic introgression in population genetic data by being robust to different demographic models.

The paper investigates whether forensic STRs correlate with gene expression levels, finding six significant associations that may compromise medical privacy.

The paper benchmarks five Y-chromosomal haplogroup classifiers using whole-genome and whole-exome sequencing data, finding YLeaf performs best for both and handles third-generation sequencing data effectively.

This study analyzes genome-wide data from 1,433 ni-Vanuatu individuals to trace their genetic ancestry and admixture history, revealing synchronous admixture events and social assortative mating patterns.

This study analyzes 8.5 million microsatellite regions across three human genome datasets, identifies polymorphic sites, and demonstrates their utility in population genetics and individual identification.

This study examines genetic structure in African populations using ethnolinguistic data, finding that language classifications better capture genetic variation than geography alone.

The paper introduces a windowed kinship algorithm using sparse SNPs to estimate kinship in forensic genetics, achieving performance comparable to segment matching with fewer false associations.

This paper introduces Archetypal Analysis for efficient genetic clustering, showing it outperforms ADMIXTURE in speed and interpretability across human and canid datasets.

ERStruct estimates the number of top principal components from whole-genome sequencing data using parallel computing and GPU acceleration.

The paper analyzes genome-wide variation in the Massim region of Papua New Guinea, finding genetic patterns linked to the Kula trading tradition and suggesting genetic similarity among Kula-practicing groups.

fastGLOBETROTTER identifies, dates, and describes admixture events using haplotype information, revealing new admixture signals in European populations.

The paper analyzes Y chromosome data from Newfoundland and Labrador to show genetic evidence of a founder effect, with haplotypes primarily from English and Irish sources and some contributions from Basque, French, Portuguese, and Spanish populations.

PAPI infers parental admixture proportions and times from unphased local ancestry data, outperforming ANCESTOR in simulations and showing assortative mating in real data.

This paper evaluates nonlinear methods for visualizing and inferring population structure, finding graph-based algorithms like t-SNE and UMAP outperform PCA while neural networks perform worse.

This study evaluates the accuracy of genotype imputation for ancient genomes and finds it comparable to modern DNA, with some population-specific biases.

The paper develops a method to estimate multiple admixture events using 3-locus linkage disequilibrium, demonstrating its accuracy on simulated data and applying it to Colombian and Mexican populations.

This paper introduces a Hamiltonian Monte Carlo algorithm with strict convergence criteria to reduce run-to-run variability in forensic DNA mixture deconvolution without increasing runtime.

This study analyzes ancient DNA from the Swahili coast to trace genetic admixture between African and Asian populations over time.

The paper estimates X chromosome effective population size using IBD segments and applies it to infer sex-specific demographic history from UK Biobank data.

This study re-analyzes genetic data from Thailand to challenge previous conclusions about the genetic continuity between Kra-Dai speakers and Austroasiatic populations, revealing a more complex genetic history.

The paper analyzes ancient genomes from Northeast Brazil and compares them to other ancient and present-day data, revealing migration routes along South America's Atlantic coast and unexpected ancestry signals.

The paper reports admixture between Neolithic farmers and Mesolithic hunter-gatherers in the Danube Gorges, supported by palaeogenomic analysis and archaeological findings.