Forensic and Genetic Research

Loter is a software package for local ancestry inference across species, showing robustness to admixture time and outperforming existing tools in simulations.

This paper analyzes ancient genomes from North Africa to show prehistoric migrations brought genetic influences from both the Levant and Europe to the Maghreb.

This paper introduces a stainless-steel mortar and pestle design for efficient ancient bone fragmentation, improving sample throughput and ease of use.

This paper introduces CubSFS, a method to estimate population size changes from the site frequency spectrum using cubic splines and validates it on simulated and human population data.

The paper analyzes ancient DNA from Southeast Asia to show multiple waves of migration, including an initial spread of Austroasiatic languages and a later influx linked to Bronze Age populations.

This study uses haplotype sharing among Finns to reconstruct recent population history and identify regions with increased rare disease variant sharing.

The paper develops a tool to estimate genetic kin relationships in prehistoric populations using degraded ancient DNA data, revealing previously unknown family ties.

GrigoraSNPs optimizes SNP calling in DNA forensics by improving runtime efficiency for high-throughput sequencing data.

This study compares two DNA extraction methods for ancient samples from tropical environments, finding Method D better for fragmented DNA recovery.

The paper identifies 30 InDel markers for forensic identification and population genetics analysis in the Chinese Xinjiang Hui group, showing high discriminatory power and genetic similarity to Han populations.

The paper develops a targeted RNA sequencing assay to identify forensic body fluids using specific gene markers and demonstrates its sensitivity and specificity in single-source and admixed stains.

The paper analyzes additional mtDNA sequences from Thailand and Laos to explore the genetic history of Tai-Kadai and Sino-Tibetan-speaking populations in Mainland Southeast Asia, finding evidence for both demic diffusion and admixture.

This study uses ancient DNA data to show that the spread of the Beaker Complex to Britain was primarily due to migration, replacing most Neolithic gene pool and introducing Steppe ancestry.

Ancient DNA from 223 people (12,000-500 BCE) reveals a west-east hunter-gatherer cline, largely unadmixed farmers, Caucasus-shifted Aegean farmers, and Balkan steppe ancestry almost 2,000 years early.

The paper uses simulations and Bayesian methods to show a simple range-expansion model explains much of human genetic diversity.

The paper identifies shared signatures of recent positive selection across 20 human populations and links them to potential biological mechanisms.

The paper compares Runs of Homozygosity (ROH) detected from SNP array and low coverage whole genome sequence data to establish guidelines for combining datasets.

This paper uses haplotype-based methods to reveal genetic structure in Ireland, showing regional diversity and historical migrations, with implications for genetic association studies.

The paper introduces MultiWaver, a method to infer multiple-wave admixture histories from ancestral tracks, validated on real datasets.

The paper analyzes maternal and paternal genetic variation in Thai hunter-gatherer groups, finding distinct haplogroup patterns and suggesting a recent origin for the Mlabri population.

The paper develops a population-genetic framework to model mitochondrial heteroplasmy inheritance and applies it to infer genetic drift and mutation rates during human development.

The paper analyzes genomic data from Mesolithic Scandinavians to show two colonization routes and genetic adaptations to high-latitude environments.

The paper analyzes maternal genetic structure in Namib Desert populations to evaluate peopling hypotheses, finding strong Bantu influences and endogamous matriclanic systems.

The paper introduces a new formula for efficiently calculating P(RMNE) in DNA mixture analysis to handle larger SNP panels without computational artifacts.

The paper improves the D-statistic for detecting ancient admixture by using all reads and error correction, showing better performance at low sequencing depth.

The paper analyzes ancient mitochondrial DNA from the Iberian Peninsula to study maternal genetic changes from the Neolithic to the Early Bronze Age, finding regional continuity and distinct population history compared to Central Europe.

The paper proposes a simulation model and software to estimate the number of males with a matching Y-chromosome profile, addressing challenges in forensic DNA evidence evaluation.

The paper analyzes ancient DNA data from Neolithic and Chalcolithic Europe to study population dynamics and admixture patterns across different regions and time periods.

This study shows that introgression and gene flow from ancient populations create a wave in inferred effective population size, affecting population history estimates.

This study detects ancient positive selection in humans by identifying genomic regions where Neandertals and Denisovans fall outside present-day human variation, finding evidence for regulatory changes associated with human-specific traits.