Cell Adhesion Molecules Research

The paper investigates how collagen and DDR-2 signaling coordinate integrin adhesion between adjacent tissues in C. elegans.

The paper identifies new interactors of LINKIN (ITFG1) and shows their role in cell migration and tissue integrity in C. elegans and human breast cancer cells.

The paper identifies a Dystroglycan-Laminin-Integrin axis that directs cell basal geometry remodeling in the developing Drosophila retina by patterning the basement membrane.

This study identifies nidogen-2 as a physical and genetic interaction partner of hemicentin-1, showing their cooperative role in basement membrane integrity.

The paper identifies a surface on PAT-4 that interacts with UNC-112 through genetic analysis in C. elegans.

This study shows that integrin function is required for maintaining cellular organisation and shape during Drosophila egg chamber morphogenesis, but not for pre-follicle cell polarity.

This study shows that non-junctional cadherin3 regulates cell migration and contact inhibition of locomotion by oppositely controlling Rac1 through extracellular and cytoplasmic domains without cell-cell contact.

The paper determines the structures of engineered knottins 2.5F and 2.5D in complex with integrin αVβ3 and reveals structural mechanisms underlying their differential binding to αVβ3 and α5β1.

This study shows Nck1, but not Nck2, mediates shear stress-induced endothelial permeability through distinct signaling mechanisms.

The paper uses evolutionary rate covariation analysis to identify genes coevolving with Drosophila E-cadherin, revealing novel regulators of cell adhesion and actin dynamics.

This paper investigates the role of Nidogen/entactin in basement membrane assembly and morphogenesis in Drosophila, showing tissue-specific requirements and functional domains of Ndg.

The paper shows integrin signaling suppresses filopodia in Drosophila myotubes during muscle-tendon attachment, enabling actin machinery to form strong attachments.

The paper identifies new functions of integrin-associated proteins in Drosophila myotendinous junctions, revealing their roles in regulating adhesion and mechanotransduction.

The paper shows that integrin adhesion and PDGFr signaling work together to drive directional migration of Xenopus mesendoderm cells without PDGF-A ligand.

This study shows plakoglobin is essential for morphogenetic events by regulating cell-cell and cell-matrix adhesion during Xenopus gastrulation.

ProLIF quantitatively measures integrin-protein interactions in proteoliposomes using flow cytometry, enabling analysis of membrane effects on protein recruitment.