Wnt/β-catenin signaling in development and cancer

The paper identifies mutations in SACK1G that disrupt its interaction with CK1α, using computational modeling and experimental validation.

This study shows TNFR1 promotes colonic mesenchymal cell diversity and stem cell niche function, with TNFR1 deficiency reducing cell diversity and impairing stem cell maintenance.

The paper investigates TCF7L2 isoform redundancy in thalamic development, finding β-catenin-independent regulation and a developmental switch in activity.

The paper shows that Wnt/β-catenin signaling via wnt10a inhibits NF-κB to induce osteoblast dedifferentiation in zebrafish, which is also observed in cardiomyocytes during heart regeneration.

The paper compares the activities of canonical Wnt ligands in human pluripotent stem cell differentiation and finds differences in their ability to induce mesodermal and ectodermal markers.

This study shows that AXIN1 mutations in HCC lead to reduced Wnt/β-catenin activity and increased YAP/TAZ signaling, enabling niche-independent growth.

This study identifies TOE1 as a novel β-catenin interactor in myeloid cells that modulates Wnt signaling via LEF-1 and regulates proliferation through PAK2.

This study identifies zonation disruption, specifically aberrant β-catenin expansion, as a novel driver of hepatocellular carcinoma in chronic liver disease, revealing a distinct human HCC subtype with therapeutic implications.

This study shows that β-catenin condensation drives the clustering of the cadherin/catenin complex and the formation of new cell-cell junctions.

This study identifies Mena as a key mediator of Wnt signalosome endocytosis, showing it promotes Wnt signaling by binding LRP5/6 and facilitating receptor uptake.

The paper develops a mechanistic model to resolve debates on how receptor trafficking and membrane organization influence Wnt/β-catenin signaling, revealing a compensatory recycling mechanism and the role of ordered domains in signalosome stability.

This paper presents cryo-EM structures of PORCN with inhibitors, revealing a conserved water-mediated binding mechanism for rational drug design.

This study shows Lgr5+ stem cells maintain intestinal epithelial homeostasis and drive regeneration after injury through WNT signaling.

The paper identifies how differential TCF7L2/LEF1 binding specificity of {beta}-catenin shapes distinct gene regulatory outcomes in liver tumors.

This study shows that WNT signaling enhances NF-κB activation and drug resistance in KRAS-mutant colorectal cancer, suggesting a therapeutic strategy targeting WNT and MEK pathways.

This study shows chemotherapy induces a Wnt-active diapause-DTP state in breast cancer cells, which can be targeted by combined Wnt and chemotherapy inhibition.

This study identifies SREBP2 as a direct APC-AXIN1 substrate degraded via a β-catenin-independent pathway, regulating cholesterol metabolism and providing a target for APC-mutant colorectal cancer.

This study shows Wnt induces FZD5/8 endocytosis and degradation via ZNRF3/RNF43, with RSPO1 stabilizing FZD5/8 and DVL promoting ligand-independent endocytosis.

This study identifies a novel interaction between Dvl2 and profilin2, revealing that profilin2 binds to the extreme-C-terminus of Dvl2 independently of the PDZ or DEP domains and remains active even when Dvl2 is autoinhibited.

This study identifies WNK kinases as regulators of RNF43, showing they control RNF43 membrane levels and WNT signaling, with implications for cancer therapy.

This paper identifies a therapeutic strategy using WNT hyperactivation to kill colorectal cancer cells while rejuvenating healthy intestinal tissue.

This study shows ETEC heat-labile toxin stabilizes β-catenin and alters intestinal epithelial differentiation, leading to impaired nutrient absorption and growth issues.

The paper shows Sfrp1a regulates zebrafish HSPC development and differentiation in a dose-dependent manner, with loss or gain of function affecting HSPC numbers and lineage differentiation.

This paper reports the structure of the FZD4-Tspan12 complex and shows how Tspan12 enhances Norrin signaling by facilitating trafficking and higher-affinity Norrin binding.

This study shows that degrading tankyrase (TNKS) with PROTACs overcomes the limitations of catalytic inhibitors by preventing AXIN puncta formation and enhancing WNT/β-catenin pathway suppression in colorectal cancer.

The paper identifies Trip12 as an E3 ubiquitin ligase that ubiquitinates Fzd9b, reducing its availability and Wnt9a/Fzd9b signaling in zebrafish hematopoietic stem cells.

The paper identifies a Wnt-induced phospho-switch in DVL3 that regulates its interaction with Frizzled receptors and Wnt/β-catenin signaling through conformational changes.

This study identifies NEK9 as a driver of docetaxel resistance in cancers and shows that its ablation sensitizes cells to docetaxel via ERK-mediated pyroptosis, suggesting fostamatinib as a potential therapeutic partner.

This study shows that loss of WNT2B promotes colorectal cancer progression in mouse models and is associated with poor patient survival in human samples.

This study identifies IQGAP3 as a Wnt signaling mediator that stabilizes β-catenin by disrupting Axin1-CK1α interaction and is itself regulated by Wnt signaling.