Matthias Krause

This study identifies Mena as a key mediator of Wnt signalosome endocytosis, showing it promotes Wnt signaling by binding LRP5/6 and facilitating receptor uptake.

This study identifies Endophilin, Lamellipodin, and VASP as key components in fast endophilin-mediated endocytosis that regulate actin polymerization through liquid-like condensates.

This study identifies NHSL3 as a regulator of actin dynamics by interacting with Ena/VASP proteins and the Scar/WAVE complex, inhibiting Arp2/3 activity to promote cell migration.

This study identifies the NHSL1-A complex as a regulator of cell migration and chemotaxis by interacting with the Arp2/3 complex and modulating lamellipodia dynamics.

This study identifies NHSL1's role in promoting fast endophilin-mediated endocytosis by interacting with EndoA2 and Ena/VASP proteins, enhancing actin polymerization at FEME sites.

This study shows that GSK3 and Lamellipodin regulate lamellipodia formation and focal adhesion maturation in mouse neural crest migration.

The paper identifies four Hsa21-orthologous genes, including Dyrk1a, that cause craniofacial dysmorphology in Down syndrome mouse models by reducing neural crest cell proliferation.

This study shows that dual loss of NDR1/2 kinases in neurons causes neurodegeneration, disrupts endocytosis, and impairs autophagy by affecting membrane trafficking and protein homeostasis.

This study identifies GSK3's role in regulating neural crest migration and shows its relevance in neuroblastoma cell migration.